皮质下血管性认知障碍的脑功能网络研究  

Analysis of functional brain networks in patients with subcortical vascular cognitive impairment

作　　者：汪耀[1] 孙雅文[1] 徐群[2] 陈雪[1] 丁伟娜[1] 周滟[1] 唐辉[1] 董荃[2] 许建荣[1] 

机构地区：[1]上海交通大学医学院附属仁济医院放射科,上海200127 [2]上海交通大学医学院附属仁济医院放神经内科,上海200127

出　　处：《中华行为医学与脑科学杂志》2015年第8期698-701,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金项目（81171325）;上海市科委西医引导项目（14411964400）

摘　　要：目的 利用基于图论的复杂网络理论探讨皮质下血管性认知障碍（SVCI）患者的静息态脑功能网络改变及其相关的影像学诊断特征.方法 收集SVCI患者34例,对照22例.对所有被试进行神经心理学评估,包括简易智能状态检查（mini-mental state examination,MMSE）和蒙特利尔认知评估量表（Montreal cognitive assessment,MoCA）等,并采集全脑静息态fMRI数据.利用基于图论的复杂网络理论构建大脑功能网络.结果 ①SVCI组与对照组的脑功能网络均具有“小世界”属性.②SVCI组节点度在左侧额下回三角区（-45.58,29.91,13.99）、左侧舌回（-14.62,-67.56,-4.63）减小,在右侧中央前回（41.37,8.21,52.09）、右侧岛盖（52.65,-6.25,14.63）、左侧颞上回（-53.16,-20.68,7.13）、右侧颞上回（58.15,-21.78,6.80）、左侧颞中回（-55.52,-33.80,-2.20）增大;SVCI组介数中心度在左侧额下回三角区（-45.58,29.91,13.99）,右侧前扣带和旁扣带回（8.46,37.01,15.84）,右侧枕中回（37.39,-79.70,19.42）,左侧顶下缘角回（-42.80,45.82,46.74）减小,在右侧中央前回（41.37,-8.21,52.09）,右侧岛盖（52.65,-6.25,14.63）,左侧枕下回（-36.36,-78.29,-7.84）,左侧梭状回（-31.16,-40.30,-20.23）增大.③左侧舌回节点度及左侧额下回三角区介数中心度与MoCA评分呈显著正相关;左侧舌回和左侧额下回三角区节点度及左侧额下回三角区介数中心度与MMSE评分呈显著正相关.结论 SVCI组与对照组的脑功能网络均具有“小世界”属性,SVCI患者部分脑区的节点属性异常有助于揭示相应临床认知功能障碍的发生机制.Objective To investigate the change of the resting-state brain function of patients with Subcortical Vascular Cognitive Impairment （SVCI） by complex network theory which is based on the graph theory and determine the possible imaging characteristics.Methods 34 patients with SVCI and 22 controls were recruited.All of them were interviewed using a set of neuropsychological tests including mini-mental state examination （MMSE） and Montreal cognitive assessment（MoCA）,and were subject to the MRI scan.Based on the acquired data,functional network were constructed for the subsequent analysis.Results Both of the two groups showed small-world attributes.The node degree of SVCI group was significantly decreased in the left triangular part of inferior frontal gyrus （-45.58,29.91,13.99） and left lingual gyrus （-14.62,-67.56,-4.63）,and significantly increased in the right precentral gyrus（41.37,8.21,52.09）,right rolandic operculum（52.65,-6.25,14.63）,left superior temporal gyrus（-53.16,-20.68,7.13）,right superior temporal gyrus（58.15,-21.78,6.80） and left middle temporal gyrus（-55.52,-33.80,-2.20）.The betweenness centrality of the SVCI group significantly decreased in the left triangular part of inferior frontal gyrus （-45.58,29.91,13.99）,right anterior cingulate/paracingulate cortex （8.46,37.01,15.84）,right middle occipital gyrus （37.39,-79.70,19.42） and left angular gyrus （-42.80,45.82,46.74）,while it was significantly increased in the right anterior central gyrus（41.37,-8.21,52.09）,right rolandic operculum （52.65,-6.25,14.63）,left inferior occipital gyrus （-36.36,-78.29,-7.84） and left fusiform gyrus （-31.16,-40.30,-20.23）.Node degree of left lingual gyrus and betweenness centrality of the left triangular part of inferior frontal gyrus had significantly positive correlation with MoCA.Node degree of left lingual gyrus and the left triangular part of inferior frontal gyrus and betweenness centrality of the left triangular part of inferior frontal gyrus had

关 键 词：皮质下血管性认知障碍 磁共振成像 脑网络 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]