精神病超高危人群认知功能的对照研究  

A comparative study of cognitive functions in individuals at ultra high-risk for psychosis

作　　者：王中磊[1,2] 侯彩兰[2] 唐毅[2] 贾福军[2] 

机构地区：[1]南方医科大学,广州510515 [2]广东省人民医院(广东省医学科学院),广东省精神卫生中心

出　　处：《中华行为医学与脑科学杂志》2015年第8期706-709,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：卫生行业科研专项一精神病风险综合征预警因素与精神病综合征转化的研究（201002003）

摘　　要：目的 探讨精神病超高危人群（ultra high-risk for psychosis,UHR）与首发精神分裂症患者及健康对照认知功能的差异.方法 分别选取来自首发精神分裂症组一级亲属的精神病超高危（24例）、首发精神分裂症患者（23例）及健康对照30例作为被试,采用连线测验（trail making test,TMT）、Stroop颜色单词测验和持续操作测验（continuous performance test,CPT）测试被试的信息处理速度和持续注意力.结果 ①UHR组连线测验时间[（45.12±14.87）s]短于精神分裂症组[（60.43± 19.30）s],长于健康对照组[（27.13±7.74）s];UHR组Stroop色词测验评分[（28.46±7.87）分]高于精神分裂症组[（18.78±6.86）分],低于健康对照组[（43.40±9.64）分];UHR组持续操作测验均分[（1.86±1.05）分]高于精神分裂症组[（1.17±0.67）分],低于健康对照组[（2.63±0.67）分],均差异有统计学意义（P＜0.01）.②将年龄、受教育年限、工作状况、婚姻状况及阳性和阴性症状量表（the positive and negative syndrome scale,PANSS）得分作为协变量进行协方差分析后,三组间在连线测验及Stroop颜色单词测验差异仍有统计学意义.结论 精神病超高危人群存在认知功能的改变,其认知功能居首发精神分裂症患者和健康人群之间.Objective To investigate the differences of cognitive functions among ultra high-risk individuals（UHR）,first-episode schizophrenia patients and healthy controls.Methods Twenty four participants meeting clinical inclusion criteria for initial prodromal states （IPS） selected from the first degree relatives of schizophrenia,23 first onset schizophrenia patients from the same family with UHR as well as 30 healthy controls were assessed with a comprehensive neuropsychological test battery including Trail Making Test （TMT）,Stroop color word test and the Continuous Performance Test （CPT） to test the speed of information processing and sustained attention ability.Results ①The time of the Trail Making Test in UHR （（45.12±14.87） s） was shorter than first-episode schizophrenia patients（（60.43± 19.30）s）,but longer than healthy controls（（27.13±7.74） s）.The whole score of the Stroop color word test in UHR （28.46± 7.87） was higher than first-episode schizophrenia patients （18.78± 6.86）,and lower than healthy controls （43.40±9.64）.The score of the Continuous Performance Test in UHR （1.86 ± ± 1.05） was significanly higher than first-episode schizophrenia patients（1.17±0.67）,but lower than healthy controls （2.63±0.67）,and all these differences were significant （P〈0.01）.②Taking age,years of education,occupation status,marital status and the Positive and Negative Syndrome Scale （PANSS） scores as the covariance,the analysis of covariance showed TMT and Stroop color word test were still statistically significant.Conclusion There are cognitive function changes in individuals at ultra high-risk for psychosis,lying between first-episode schizophrenia cases and healthy controls.

关 键 词：精神病超高危 认知功能 首发精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]