急性缺血性脑卒中患者血清中白细胞介素-33的表达及其临床意义  

Expression and clinical significance of interleukin-33 in patients with acute ischemic stroke

作　　者：胡也华[1] 欧阳锋[2] 

机构地区：[1]金华市中心医院神经内科,浙江金华321000 [2]海南省人民医院神经内科,海口570311

出　　处：《中国临床药理学杂志》2015年第17期1718-1720,共3页The Chinese Journal of Clinical Pharmacology

基　　金：海南省自然科学基金资助项目(310133)

摘　　要：目的探讨白细胞介素-33在急性缺血性脑卒中患者血清中的表达及其临床意义。方法用酶联免疫吸附法检测100例急性缺血性脑卒中患者(试验组)和30例健康志愿者(对照组)的血清中白细胞介素-33、肿瘤坏死因子-α、C反应蛋白、白细胞介素-1β的表达,并进行相关性分析。结果与对照组相比,试验组血清中的白细胞介素-33、肿瘤坏死因子-α、C反应蛋白和白细胞介素-1β的表达明显升高(P<0.05)。白细胞介素-33与肿瘤坏死因子-α和白细胞介素-1β的表达呈正相关(P<0.05)。结论早期检测白细胞介素-33对于判断急性缺血性脑卒中患者的疾病状况可能具有一定的临床意义。Objective To determine the expression of serum interleukin- 33（ IL- 33） levels and its association with functional outcome in patients with acute ischemic stroke. Methods One hundred hospitalized patients with acute ischemic stroke within 24 h after onset were used as treatment group. A parallel group of 30 healthy volunteers were used as control group. Serum samples were collected for the measurement of C- reactive protein,interleukin- 33,tumor necrosis factor- α and interleukin- 1β levels and their correlation to acute ischemic stroke was analyzed. Results The serum C- reactive protein, tumor necrosis factor- α,interleukin- 1β,interleukin- 33 levels in treatment group were significantly higher than that in control group. Furthermore,serum interleukin- 33 levels increased with the tumor necrosis factor- α and interleukin- 1β levels（ P〈 0. 05）. Conclusion Interleukin- 33 may be involved in the pathogenesis and / or progression of acute ischemic stroke.

关 键 词：急性缺血性脑卒中 白细胞介素-33 肿瘤坏死因子-Α C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R969.4[医药卫生—临床医学]