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出 处:《江苏医药》2015年第17期2036-2038,共3页Jiangsu Medical Journal
摘 要:目的探讨人表皮生长因子受体2(HER-2/neu)原癌基因在胃癌组织中的表达及其临床意义。方法检测55例胃癌患者术后标本中HER-2/neu的表达,分析其在不同组织类型胃癌中的表达差异及其与临床病理的相关性。结果55例胃癌组织中,HER-2/neu表达阳性率43.6%(24/55),其在不同组织类型的胃癌中表达无统计学差异(P>0.05)。HER-2/neu的表达与胃癌浸润深度、淋巴结转移和临床分期密切相关(r=0.375,r=0.380和r=0.488,P<0.05)。HER-2/neu表达阳性的患者无病生存期及总生存期均低于表达阴性者(P<0.05)。结论 HER-2/neu在胃癌组织中的表达与其生物学行为密切相关;检测HER-2/neu表达对胃癌治疗的选择和预后的评估有一定意义。Objective To investigate the expression and clinical significance of human epidermal growth factor receptor-2(HER-2/neu) gene expression in gastric carcinoma. Methods The expression of HER-2/neu gene in paraffin samples of 55 gastric carcinoma was detected by immunohistochemical staining. The difference of HER-2/neu expression among different kinds of gastric carcinomas and relationship of HER-2/neu expression and clinicopathological parameters were analyzed. Results The positive expression rate of HER-2/neu in 55 gastric carcinomas was 43. 6~, which was not significantly different among different kinds of gastric carcinoma (P〉0. 05). The expression of HER-2/neu was positively correlated with the depth of invasion, lymph node metastasis and TNM stage(r= 0. 375, r= 0. 380 and r: 0. 488, P〈0. 05). The disease-free survival time and overall median survival time were lower in the cases with positive expression of HER-2/neu than those with negative expression of HER-2/neu(P〈0. 05). Conclusion The expression of HER-2/neu is closely related to the biological behaviorg of gastric carcinoma. The detection of HER-2/neu expression has a certain value in the treatment and prognosis evaluation of the patients with gastric carcinoma.
关 键 词:胃癌 人表皮生长因子受体2
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