先期化疗在晚期卵巢癌患者治疗中的应用评价  

The clinical evaluation of primary chemotherapy application in the patients with advanced ovarian cancer

作　　者：年妍[1] 刘满梅[1] 哈春芳[1] 王瑞[2] 李望舒[2] 

机构地区：[1]宁夏医科大学总医院妇科,宁夏银川750004 [2]宁夏医科大学,宁夏银川750004

出　　处：《宁夏医学杂志》2015年第9期823-826,共4页Ningxia Medical Journal

基　　金：宁夏科技支撑计划资助项目(2013ZYS090)

摘　　要：目的探讨先期化疗在晚期卵巢癌患者治疗中的应用评价。方法回顾性分析行先期化疗及先期手术治疗的晚期卵巢癌患者60例,通过比较相关指标对两种治疗方式的疗效进行评价。结果治疗前2组患者的年龄、实体瘤大小、CA125水平、FIGO手术分期、病理类型及组织分化程度,差异无统计学意义（P〉0.05）;先期化疗组术前一般状况（ZPS评分0～1分所占比例,80.00%）明显高于先期手术组（36.70%）,先期化疗组腹水控制率（100.00%）及治疗后总有效率（72.41%）均高于先期手术组（58.62%与44.83%）,差异有统计学意义（P〈0.05）;先期化疗组在手术时间、术中出血量、术后通气时间及术后血象恢复时间上均优于先期手术组,差异有统计学意义（P〈0.05）;先期化疗组减瘤术的满意率（66.67%）明显高于先期手术组（33.33%）,差异有统计学意义（P〈0.05）;2组患者术后并发症发生率,先期化疗组（6.67%）与先期手术组（10.00%）,差异统计学意义（P〉0.05）。结论先期化疗能使晚期卵巢癌患者的术前一般状况得到有效改善,增加手术耐受性,进而使得晚期卵巢癌患者肿瘤细胞减灭术的满意率及安全性大大提升,利于患者术后恢复。Objective To study the applications of primary chemotherapy in patients with advanced ovarian cancer.Methods 60 patients with advanced ovarian cancer were retrospectively analyzed,and including primary chemotherapy group and primary debulking surgery group（n = 30）. The curative effect of two kinds of treatments was evaluated by comparing the relevant indicators.Results The age of the two groups of patients before treatment,solid tumor size,CA125 levels,FIGO,surgical staging,pathological type and tissue differentiation degree,there was no statistical significance difference（P〉0. 05）; primary chemotherapy group preoperative general conditions（ZPS score 0 ～ 1 branch） and percentage（80. 00%） was significantly higher with the first surgical group（36. 70%）,there was statistically significant difference（P〈0. 05）; Two groups of ascites control efficient in primary chemotherapy group（100. 00%）,and primary debulking surgery group（58. 62%） and the total effective rate before and after the treatment in primary chemotherapy group（72. 41%）,primary debulking surgery group（44. 83%）,there was statistically significant difference（P〈0. 05）;primary chemotherapy group in operation time,intraoperative blood loss,postoperative recovery time of ventilation time and postoperative blood picture on are better than the primary debulking group,difference has statistical significance（P〈0. 05）; early chemotherapy group decrease tumor surgery（66. 67%） was significantly higher satisfaction with the first surgical group（33. 33%）,there was statistically significant difference（P〈0. 05）; two groups of postoperative complications primary chemotherapy group（6. 67%）,primary debulking group（10. 00%）,there was no obvious statistical significance difference（P〉0. 05）. Conclusion Primary chemotherapy can effectively improve preoperative status of advanced ovarian cancer patients,increase the tolerance,which makes the satisfaction of patients with advanced ovarian cancer tu

关 键 词：先期化疗 先期手术 晚期卵巢癌 疗效评价 

分 类 号：R737.31[医药卫生—肿瘤]