长非编码RNA与其他表观遗传机制的相互调控在肿瘤中的作用机制  

Functional mechanism of the mutual regulation between long non-coding RNAs and other epigenetic mechanisms in cancer

作　　者：党旖旎[1] 张国新[1] 

机构地区：[1]南京医科大学第一附属医院消化内科,210029

出　　处：《国际肿瘤学杂志》2015年第9期671-674,共4页Journal of International Oncology

基　　金：国家自然科学基金（81270476、81470830）

摘　　要：长非编码RNA（1ncRNA）的异常表达与多种肿瘤相关。最新研究发现，lncRNA一方面可以通过多种途径调控其他表观遗传方式，包括DNA甲基化、组蛋白修饰、miRNA、染色质重构；另一方面，其他表观遗传形式也能够调控lncRNA的表达，两者的相互调控对恶性肿瘤的发生和发展起着重要作用。对其中机制的深入研究有助于更加清晰地阐明肿瘤的发生机制，并为以lncRNA为靶点的肿瘤治疗提供理论基础。Abnormal expressions of long non-coding RNAs （LncRNAs） are associated with a variety of tumors. Recent studies show that lncRNA can regulate other epigenetic processes such as DNA methylation, histone modifications, chromatin remodeling and miRNA through various ways; on the other side, other epige- netic processes can influence the expression of lncRNA. The mutual regulation of them paly important roles in the occurrence and development of malignant tumors. The better understanding of the crosstalk between lncRNA and epigenetic modulation will contribute to clearly clarify the mechanism of tumor, which provides a theoretical basis for the anti-cancer therapies targeting lncRNAs.

关 键 词：RNA 后成说 遗传 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]