骨肉瘤中医证型与方药分析研究  

Study on TCM Patterns / Syndromes of Osteosarcoma and Formula Analysis

作　　者：司富春[1] 丁帅伟[1,2] 

机构地区：[1]河南中医学院中医药分子生物学实验室,河南郑州450046 [2]河南中医学院

出　　处：《世界中西医结合杂志》2015年第7期903-907,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：国家回国留学人员基金优秀项目(2007)170;河南省国际科技合作项目(104300510019);河南省科技创新团队项目(2010-29);河南省中医学博士后科技创新团队(2012)

摘　　要：目的收集1979年1月至2014年12月中国知网(CNKI)中中医诊断治疗骨肉瘤的文献,分析其中医证型和方药特点,以探讨骨肉瘤中医辨证论治规律。方法运用SPSS17.0统计软件对症状、证型、方剂、药物、证候要素和脏腑病位进行频数分析,进而运用系统聚类分析法对症状和药物进行聚类分析。结果所选文献中共出现证型26个,其中血瘀证、痰瘀互结证、肾阳虚证、脾肾阳虚证、气血两虚证,肾阴虚证为常见证型,共占54.20%;症状聚类分析,得出肾阴虚、脾肾阳虚、气滞血瘀、痰热结聚四个证型;证候病机以血瘀、阳虚、痰阻较常见;脏腑病位主要涉及肾、肝、脾。共得方剂119首,其中成方归为7类,以补益剂、理血剂、温里剂为主,自拟方以祛风除湿、理气化痰、活血化瘀止痛等治法进行组方。所用中药239味,按功能归为19大类,补虚、活血化瘀、清热药物使用频次共占62.27%;药物主要归经为肝经、脾经、心经、肾经、肺经,占82.05%;通过聚类分析,得出5个聚类方,适用于气虚血瘀型,肾阳虚衰、寒凝血脉,肾阴不足、筋弱足痿,痰瘀互结、筋骨失养,阳虚血亏,寒凝痰滞等证型的骨肉瘤。结论中医对骨肉瘤的病因病机的分析、辨证分型、遣方用药的临床研究结果可为目前该病的辨证论治提供参考。Objective To explore the law of pattern/ syndrome differentiation and treatment determi-nation of traditional Chinese medicine（TCM）for osteosarcoma through the analysis on TCM patterns/ syn-dromes and formula characters in the literatures on TCM diagnosis and treatment of osteosarcoma in CNKI collected from January 1979 to December 2014. Methods SPSS17. 0 software was used for the frequency a-nalysis in terms of the elements of symptoms,patterns/ syndromes,formulas,medicines and syndromes as well as zangfu location. The cluster analysis was adopted for the symptoms and medicines. Results Totally,26 patterns/ syndromes were collected from the literatures and the common ones were blood stagnation,interac-tion of phlegm and stasis,kidney yang deficiency,spleen and kidney yang deficiency,qi and blood deficiency and kidney yin deficiency,accounting for 54. 20% . The symptom cluster analysis resulted in kidney yin defi-ciency,spleen and kidney yang deficiency,qi and blood stagnation and interaction of phlegm and heat. Blood stagnation,yang deficiency and phlegm blockage were the common pathogenesis of the syndromes. The affect-ed zangfu organs were kidney,liver and spleen. Totally,119 formulas were included,of which,the patent for-mulas were classified into 7 categories,focusing mainly on tonics formula,formula for regulating blood,formu-la for warming the interior. The self - prepared formulas were for eliminating wind and damp,regulating qi cir-culation,resolving phlegm,activating blood and resolving stasis to stop pain,etc. Of all the involved 239 herbs,in 19 categories in terms of actions,the percentage of the use frequency was 62. 27% for the herbs of reinforcing in deficiency,activating blood circulation,resolving stasis and clearing away heat. Regarding me-ridian tropism,liver meridian,spleen meridian,heart meridian,kidney meridian and lung meridian were involved,accounting for 82. 05% . Through cluster analysis,5 clustering formulas were included for osteosarcoma differ-entiated as qi deficiency and blood s

关 键 词：骨肉瘤 中医 证型分析 方药分析 

分 类 号：R738.1[医药卫生—肿瘤]