替莫唑胺应用于脑转移瘤的研究进展  

Research-progression of Temozolomide in Brain Metastasis

作　　者：韦燕[1] 赵善琳[1] 

机构地区：[1]广西医科大学第八附属医院(贵港市人民医院)肿瘤科,广西贵港537100

出　　处：《中国医药指南》2015年第26期41-43,共3页Guide of China Medicine

基　　金：广西贵港市科学研究与技术开发计划(合同项目:贵科攻1305016)

摘　　要：脑转移性肿瘤是成人最常见的颅内恶性肿瘤,治疗手段有限,传统的治疗方法主要以放射治疗为主。替莫唑胺是新一代的烷化剂,具有透过血脑屏障起到抗肿瘤的作用,在脑胶质瘤的治疗上应用广泛,疗效确切。近年来尝试在脑转移性肿瘤上使用替莫唑胺治疗亦得到肯定疗效,替莫唑胺与其他化疗药物或放疗联合可能有助于控制肿瘤,使患者得到生存获益。本文就国内外使用替莫唑胺治疗脑转移瘤的现状进展进行综述。Brain metastases are most common intracranial malignant tumors in adults, with the progress of tumor treatment means, the better curative effect of malignant tumor and the longer survival time, the incidence of brain metastases increase. That will be serious impact on quality of life. Treatment of brain metastases is limited, radiation therapy is the traditional one. As a new generation of alkylating agent temozolomide, which show antitumor effects by through the blood-brain barrier, widely used in the treatment of glioma. In recent years attempts to using temozolomide therapy metastatic cancer also effective. This paper summarize using temozolomide in the treatment of brain metastases.

关 键 词：替莫唑胺 脑转移瘤 疗效 

分 类 号：R739.41[医药卫生—肿瘤]