RING1表达与垂体腺瘤KNOSP分级关系的实验研究  

Relationship between ring finger protein 1 expression and KNOSP grading in pituitary adenomas

作　　者：胡正[1] 杨少春[1] 黎玉婷[2] 杜波[2] 邱明兴 李煜[2] 郝文文[2] 彭玉平[1] 

机构地区：[1]赣南医学院第一附属医院神经外科,赣州341000 [2]南方医科大学南方医院神经外科,广州510515

出　　处：《中华神经医学杂志》2015年第9期865-868,共4页Chinese Journal of Neuromedicine

基　　金：广东省自然科学基金项目（S2011010005643）;广东省科技计划项目（20128010200026）

摘　　要：目的观察垂体腺瘤组织环指蛋白1（RING1）的表达及其与垂体腺瘤KNOSP分级的关系。方法收集南方医科大学南方医院神经外科自2011年1月至2013年12月手术切除并经病理证实的人脑垂体腺瘤组织标本60例，其中KNOSP分级Ⅰ～Ⅱ级17例，Ⅲ～Ⅳ级43例。免疫组化染色检测垂体腺瘤组织R1NG1、细胞核增殖相关抗原（Ki．67）的表达。结果与Ⅰ～Ⅱ级组比较．Ⅲ～Ⅳ级组垂体腺瘤标本中R1NG1、Ki-67阳性细胞数和阳性率均较高，差异均有统计学意义（P〈0．05）。不同性别、年龄、功能分型垂体腺瘤患者标本RING1的表达强度比较差异无统计学意义f胗0．05）：与KNOSP分级Ⅰ～Ⅱ级垂体腺瘤（47．1％）比较，Ⅲ～Ⅳ级垂体腺瘤标本中R1NG1高表达率（76．7％）较高，差异有统计学意义（P〈0．05）。结论垂体腺瘤RING1的表达与KNOSP分级有关，可能是垂体腺瘤防治的新靶点。Objective To study ring finger protein 1 （RING1） gene expression in pituitary adenomas and its association with KNOSP grading. Methods Sixty human hypophysis cerebri adenoma tissue specimens, accepted surgery and conformed by pathology in our hospital from January 2011 and December 2013, were chosen in our study; KNOSP grade MI was noted 17 specimens and KNOSP grade Ill-IV was noted in 43 specimens. Immunohistochemical staining was employed to detect the expressions of RING1 and Ki-67 in pituitary adenomas. Results Specimens from KNOSP grade Ⅲ～Ⅳ had significantly larger numbers of R1NG1 and Ki-67 positive cells than those from KNOSP grade Ⅰ～Ⅱ （P〈0.05）. Pituitary adenoma specimens from different gender, age and fi.mctional classifications showed no significant difference in the R1NG1 expression （P〉0.05）; RING1 expression percentage in specimens from KNOSP grade Ⅲ～Ⅳ （76.7%） was significantly higher than that in those from grade Ⅰ～Ⅱ （47.1%, P〈0.05）. Conclusion RING1 expression is positively correlated with KNOSP grading, and deeper study about RING1 could help to find new treatment target of pituitary adenoma.

关 键 词：垂体腺瘤 环指蛋白1 细胞核增殖相关抗原 KNOSP分级 

分 类 号：R736.4[医药卫生—肿瘤]