血管中心性胶质瘤八例临床、影像与病理学分析  

Clinical, imaging and pathological findings of angiocentric gliomas： an analysis of 8 cases

作　　者：吴陈兴[1] 孔征东 姚坤[2] 刘宁[1] 齐雪岭[2] 林志雄[1] 

机构地区：[1]首都医科大学三博脑科医院神经外科,北京100093 [2]首都医科大学三博脑科医院病理科,北京100093 [3]第二炮兵总医院脑血管病研究所,北京100088

出　　处：《中华神经医学杂志》2015年第9期869-873,共5页Chinese Journal of Neuromedicine

摘　　要：目的分析血管中心性胶质瘤患者的临床、影像、病理学特点和疗效。方法首都医科大学三博脑科医院神经外科自2011年1月1日至2015年3月31日收治、经病理确诊的血管中心性胶质瘤患者8例，回顾性分析患者的临床、影像、病理学资料和疗效。结果8例患者中1例以间断头晕起病，7例以癫痫起病；肿瘤MRI表现为T1WI低信号，T2WI等、高信号。部分患者的CT显示有钙化；肿瘤WHO分级Ⅰ～Ⅱ级，镜下肿瘤细胞呈双极、圆形、卵圆形或梭形，围绕毛细血管生长．瘤细胞表达神经胶质纤维酸性蛋白fGFAP）等神经胶质细胞标记物，同时部分表达神经元核抗原（NeuN）、突触素（Syn）等神经元的标记物；手术治疗后MRI显示8例患者瘤体均全切除，随访6-47个月患者无癫痫发作、无肿瘤复发及死亡：结论血管中心性胶质瘤是一种青少年起病的低度恶性肿瘤．可能是起源于放射状胶质细胞的一种神经一胶质细胞肿瘤。手术治疗效果较好。Objective To investigate the clinical, imaging and pathological characteristics of angiocentric gliomas （AG） in Chinese patients, and provide opinions for diagnosis and treatment of the disease. Methods Eight patients with AG confirmed by histology in our hospital from January 1, 2011 to March 31, 2015, were chosen in our study; the clinical, imaging, and pathological data were retrospectively analyzed. Results In these 8 patients, one had onset of dizzy giddy and the other 7 had onset of epilepsy. Tl-weighted imaging hypointense signal and T2-weighted imaging isointense or hyperintense signals were noted. CT scan showed calcification in 3 patients. Pathology indicated WHO grade I-II gliomas. Neoplastic cells were bipolar, round, oval or spindle shaped around capillary, and they expressed both glial markers （glial fibrillary acidic protein） and neuronal markers （neuronal nuclei antigen and synaptophysin）. MR imaging showed that all the 8 patients got total resection, and follow up of 6-47 months recorded no epileptic seizure, neoplasm recurrence or death. Conclusions AG is a kind of low-grade glioma in children or young adults. And it may be a mixed neuronal-glial neoplasm originating from radial glia, enjoying good surgical effects.

关 键 词：血管中心性胶质瘤 肿瘤组织学 影像学 

分 类 号：R739.41[医药卫生—肿瘤]