中枢神经细胞瘤的诊断与治疗（附九例报告）  

Diagnosis and treatment of intracranial neurocytomas： a report of 9 cases

作　　者：肖瑾[1] 程宏伟[1] 王卫红[1] 王先祥[1] 王晓健[1] 张义泉[1] 王斌[1] 徐培坤[1] 冯春国[1] 

机构地区：[1]安徽医科大学第一附属医院神经外科,合肥230022

出　　处：《中华神经医学杂志》2015年第9期885-889,共5页Chinese Journal of Neuromedicine

摘　　要：目的探讨中枢神经细胞瘤的诊断及治疗体会。方法安徽医科大学第一附属医院神经外科自2004年1月至2014年6月共收治中枢神经细胞瘤患者9例．其中脑室内中枢神经细胞瘤（CNC）6例，脑室外神经细胞瘤（EVN）3例。回顾性分析患者的临床资料、诊断治疗及预后。结果6例CNC患者中肿瘤全切3例，次全切除2例，大部分切除1例；3例EVN患者中肿瘤全切2例，次全切除1例；CNC和EVN病理学特征相似，均可见类似神经毡样的神经纤维无核区；次全切除和大部分切除患者术后行放射治疗。随访24～72个月，无复发病例；1例患者术后出现面瘫，半年随访时好转。结论脑室内、外中枢神经细胞瘤病理学特征相似，但临床、影像学表现、预后不同。显微手术全切除肿瘤是提高患者预后的关键，术后辅以放、化疗可控制残留肿瘤的生长，延缓复发。Objective To explore the clinical manifestations, pathological features, imaging findings, microsurgical treatment effectiveness and prognosis of intraventricular central neurocytoma （CNC） and extraventricular neurocytoma （EVN）. Methods The clinical data of nine patients with intracranial neuroeytomas, admitted to our hospital from January 2004 to June 2014, were retrospectively analyzed. A comparative study of clinical manifestations, pathological features, imaging findings, microsurgical treatment effectiveness and prognosis of CNC （n=6） and EVN （n=3） was performed. Results In the six patients with CNC, total removal of the lesions was achieved in 3, subtotal removal in 2 and partial removal in 1. In the three patients with EVN, total removal of the lesions was achieved in 2 and subtotal removal in 1. The pathological features of CNC and EVN were similar, showing nerve fibers without nuclear. No recurrence was noted in 24-72 months of follow-up. Facial paralysis occurred in a young male patient and recovered after 6 months. Conclusions CNC and EVN share the same pathological characters, but have different clinical presentations, image findings and prognoses. Total removal of the tumor plays a key role in improving the prognosis of the patients. Adjuvant radiotherapy and chemical therapy can control the progress of residual tumor and delay the recurrence of it.

关 键 词：中枢神经细胞瘤 脑室 诊断 治疗 

分 类 号：R739.41[医药卫生—肿瘤]