宫颈腺癌组织中C-erbB-2与E-cadherin蛋白的表达  

Expressions of C-erbB-2 and E-cadherin in cervical adenocarcinoma tissue

作　　者：曹静[1] 吕志排[1] 党秋红[1] 郝志伟[1] 李道明[2] 

机构地区：[1]郑州大学第三附属医院病理科,郑州450052 [2]郑州大学第一附属医院病理科,郑州450052

出　　处：《郑州大学学报（医学版）》2015年第4期503-506,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省基础与前沿技术项目112300410155

摘　　要：目的:探讨宫颈腺癌组织中C-erbB-2和E-cadherin蛋白的表达与宫颈腺癌患者临床病理特征的关系。方法:应用免疫组化法检测72例宫颈腺癌组织中C-erbB-2和E-cadherin蛋白的表达情况,分析二者与宫颈腺癌患者临床病理特征的关系。结果:72例宫颈腺癌组织中,C-erbB-2高表达31例(43.1%),E-cadherin低表达34例(47.2%)。C-erb B-2高表达和E-cadherin低表达与宫颈腺癌的分化程度、FIGO分期及淋巴结转移有关(P<0.05)。宫颈腺癌组织中C-erbB-2与E-cadherin的表达呈负关联(rP=0.600,P<0.001)。结论:C-erbB-2高表达和E-cadherin低表达与宫颈腺癌的发展有关,可作为判断宫颈腺癌生物学行为的重要参考指标。Aim： To explore the expressions and clinicopathology significance of E-cadherin and C-erbB-2 in cervical adenocarcinoma tissue. Methods： The expressions of E-cadherin and C-erbB-2 protein in 72 cases diagnosed as cervical adenocarcinoma were detected by immunohistochemical method, and their relations with clinicopathological parameters were analyzed. Results： Out of 72 cervical adenocarcinoma samples, the high level expression of C-erbB-2 was found in 31 cases （43. 1% ）, while the low level expression of E-cadherin was found in 34 cases（47. 2% ）. C-erbB-2 overexpression and E-cadherin reduced expression were related with differentiation degree, FIGO staging and lymph node metastasis of cervical ade-nocarcinoma（P 〈0. 05）. There was negative association between C-erbB-2 and E-cadherin protein expressions in cervical ad-enocarcinoma tissue（rP =0. 600,P 〈0. 001）. Conclusion： C-erbB-2 overexpression and E-cadherin reduced expression may play important roles in the development of cervical adenocarcinoma, and could be used for judging its biological behavior.

关 键 词：C-ERBB-2 E-CADHERIN 宫颈腺癌 

分 类 号：R737.33[医药卫生—肿瘤]