Her-2/neu与术后复发晚期胃癌临床病理及预后的相关性研究  

The Correlation of Her-2/neu Expression with Clinicopathologic Features and Prognosis in Postoperative Recurrent Gastric Cancer

作　　者：胡晓莉[1] 王建红[1] 李春笋[1] 陈冬梅[1] 何向锋[1] 苏小琴[1] 季进锋[1] 

机构地区：[1]南通市肿瘤医院,江苏南通226361

出　　处：《肿瘤学杂志》2015年第9期730-733,共4页Journal of Chinese Oncology

基　　金：南通市科学技术局项目(S10910;W201009)

摘　　要：[目的]探讨术后复发晚期胃癌患者Her-2/neu表达及与临床病理特征和预后的相关性。[方法]分别采用免疫组织化学法（IHC）及荧光原位杂交法（FISH）对108例术后复发晚期胃癌患者进行Her-2/neu表达的检测,分析其与患者的年龄、性别、Lauren分型、组织学分级及与预后的相关性。[结果]108例患者中,IHC法检测Her-2/neu阳性表达13例,FISH法检测Her-2/neu阳性表达14例,两种方法均为阳性表达者10例,一致率为61.5%。15例正常胃黏膜中未见阳性表达。Her-2/neu表达与患者的年龄、性别、肿瘤部位、组织学分级、TNM分期、浸润深度、有无脉管浸润无关（P〉0.05）,而与患者的Lauren分型、淋巴结转移有关（P〈0.05）。Her-2/neu阳性患者的中位疾病进展时间（TTP）为22.4个月（95%CI：23.44~26.55）,阴性患者的中位TTP为25.0个月（95%CI：17.02~27.77）,两者差异无统计学意义（P=0.215）。[结论 ]Her-2/neu可能是胃癌预后不良的标志之一。[Purpose] To investigate the correlation of Her-2/neu expression with clinicopathologic features and prognosis in postoperative recurrent gastric cancer. [Methods] Her-2/neu expression was detected in 108 cases of advanced gastric cancer with recurrence postoperation by immunohistochemical method（IHC） and fluorescence in situ hybridization（FISH）,and the correlation of Her-2/neu with age,gender,Lauren type,histological grade,prognosis was analyzed. [Results] Of108 patients,there were 13 cases with positive expression of Her-2/neu by IHC,14 cases with positive expression of Her-2/neu by FISH method. There were 10 cases with positive expression of Her-2/neu in both IHC and FISH,with consistent rate of 61.5%. No expression of Her-2/neu was found in 15 cases of normal gastric mucosa. No significant correlation was found between Her-2/neu expression and the patient＇s age,gender,tumor location,histological grade,TNM stage,depth of invasion,and vascular invasion（P〈0.05）. There was significantly positive correlation between Her-2/neu expression and Lauren classification, lymph node metastasis（P〈0.05）. Median time to progression（TTP） was 22.4 months in Her-2/neu positive patients（95%CI：23.44~26.55）,and25.0 months（95% CI：17.02 ~27.77）in negative patients,without significant difference between them（P=0.215）. [Conclusion] Her-2/neu might be a predictive indicator for poor prognosis in patients with recurrent gastric cancer.

关 键 词：胃肿瘤 HER-2/NEU 预后 临床病理学 

分 类 号：R735.2[医药卫生—肿瘤]