鼻咽癌放疗后视神经损伤研究现状  

Research Progress on Radiation Induced Optic Neuropathy in Patients with Nasopharyngeal Carcinoma

作　　者：李丽[1] 王谨[1] 石磊[1] 包勇[2] 陈媛媛[1] 陈明[1] 

机构地区：[1]浙江省放射肿瘤学重点实验室浙江省肿瘤医院,浙江杭州310022 [2]中山大学肿瘤防治中心,广东广州510060

出　　处：《肿瘤学杂志》2015年第9期773-776,共4页Journal of Chinese Oncology

基　　金：广东省医学科研基金(A2011196)

摘　　要：放疗引起的视神经病变(radiation induced optic neuropathy,RION)由视神经或视交叉受到过量照射引起,是鼻咽癌放疗需尽力避免的并发症。其受到多种因素的影响,放疗的实现方式、剂量分割方式、化疗的使用、并发其他疾病等都影响RION的发生发展,但目前对治疗后RION的潜伏期、引起并发症的阈值剂量、视神经及视交叉的体积剂量效应等缺乏系统详尽的研究。文章对鼻咽癌治疗后RION的研究现状进行综述。Radiation induced optic neuropathy（RION） is a rare late complication of radiotherapy in patients with nasopharyngeal carcinoma（NPC）,resulting in rapidly progressive blindness.Management of RION remains controversial,the best option is to minimize radiation damage to eyes. The risk of toxicity might be caused by radiotherapy techniques,dose-fraction regimes,chemotherapy and complicated diseases,etc. Till now,few studies have adequate data for preclinical period of RION,threshold dose and dose-volume outcome modeling of optic nerves and chiasm. This article reviews related research progress on RION.

关 键 词：视神经病变 放射法 剂量分割 药物疗法 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]