同步热放化疗治疗在中晚期宫颈癌的应用价值  

Application value of simultaneous thermal chemoradiotherapy for advanced cervical cancer

作　　者：俞青青[1] 唐荣军[2] 楼军[3] 俞玉凤[2] 何玲红 

机构地区：[1]杭州市肿瘤医院放疗科,浙江杭州310002 [2]杭州市肿瘤医院放射物理室,浙江杭州310002 [3]杭州市肿瘤医院超声科,浙江杭州310002

出　　处：《中国妇幼健康研究》2015年第4期794-797,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨同步热放化疗治疗中晚期宫颈癌的近期疗效及对细胞增殖凋亡相关蛋白表达的影响。方法将杭州市肿瘤医院收治的80例确诊为中晚期宫颈癌的患者随机分为两组,各为40例。对照组采取同步放化疗,观察组采取同步热放化疗,比较两组近期疗效及早期不良反应情况,并检测肿瘤组织中血管内皮生长因子(VEGF)、原癌基因(c-myc)、B细胞淋巴瘤/白血病-2(Bc1-2)、热休克蛋白(HSP70)蛋白表达分布情况。结果观察组和对照组有效率分别为90.00%和75.00%,两组间差异有统计学意义(x^2=7.11,P<0.05)。两组胃肠道反应、骨髓抑制、膀胱反应及干性皮炎等不良反应发生率比较差异均无统计学意义(均P>0.05)。治疗前两组间VEGF、c-myc、Bcl-2、HSP70蛋白阳性表达强度分布情况比较差异均无统计学意义(均P>0.05);观察组治疗中VEGF和c-myc蛋白阳性表达强度分布均较治疗前明显减少(x^2值分别为8.34、9.63,均P<0.05),而HSP70蛋白阳性表达强度分布较治疗前明显增加(x^2=9.32,P<0.05),且与对照组治疗中比较差异均有统计学意义(x^2值分别为9.44、7.87、7.66,均P<0.05)。治疗中两组的Bcl-2蛋白阳性表达强度分布与治疗前比较差异均无统计学意义(均P>0.05),且两组间比较差异无统计学意义(P>0.05)。结论同步热放化疗治疗中晚期宫颈癌能取得较好的近期疗效,且安全性高,可作为中晚期宫颈癌患者的首选治疗方案。Objective To evaluate the short term effect of simultaneous thermal chemoradiotherapy on advanced cervical cancer and the influence on the expression of cell proliferation and apoptosis related protein.Methods Eighty patients diagnosed with advanced cervical cancer from Hangzhou Tumor Hospital were randomly divided into control group and observation group with 40 cases in each.The control group was given synchronous radiotherapy and chemotherapy, and the observation group was given simultaneous treatment of hyperthermia,radiotherapy and chemotherapy.The curative effect in the near future and early adverse reactions were compared between two groups, and the distribution of VEGF, c-myc, Bcl-2 and HSP70 protein expression in tumor tissue of two groups were detected.Results The efficiency of the observation group was 90.00%, and it was 75.00% in the control group.The difference between two groups was statistically significant （χ^2 =7.11,P 〈0.05）.The incidence of adverse reactions of two groups including gastrointe stinal reactions, bone marrow suppression, bladder reaction and dry dermatitis showed no significant difference （all P 〉0.05）.The distribution of protein positive expression intensity of VEGF, c-myc, Bcl-2 and HSP70 was not remarkably different between two groups before treatment （all P 〉0.05）. VEGF and c-myc protein positive expression intensity during treatment in the observation group were obviously decreased but HSP70 protein positive expression intensity was significantly enhanced compared with those before treatment （χ^2 value was 8.34, 9.63 and 9.32 respectively, all P 〈0.05）.They were significantly different from those in the control group （χ^2 value was 9.44, 7.87 and 7.66, respectively, all P 〈0.05）.The expression intensity distribution of Bcl-2 protein was not significantly different before and during treatment in two groups （all P 〉0.05）, and the difference between groups was not significant （P 〉0.05）.Conclusion Simultaneous treatment of hyperthermia,

关 键 词：放射治疗 化学治疗 热疗 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]