左侧颞下叶在面孔信息加工中的作用:一项ECoG案例研究  

Face information processing in the left inferior temporal lobe: An ECoG case study

作　　者：张烨[1,2] 邵涵钰[3] GASPAR Carl M. 陈纬[1] 朱君明[4] 汤业磊[4] 何生[3,5] 翁旭初[1,2] 

机构地区：[1]杭州师范大学认知与脑疾病研究中心,杭州311121 [2]浙江省认知障碍评估技术研究重点实验室,杭州311121 [3]中国科学院生物物理研究所,北京100101 [4]浙江大学医学院附属第二医院癫痫中心,杭州310009 [5]Departments of Psychology,University of Minnesota

出　　处：《科学通报》2015年第25期2438-2446,共9页Chinese Science Bulletin

基　　金：国家自然科学基金青年项目(31400974);国家社会科学基金重点项目(11AZD119);浙江省自然科学基金青年项目(LQ14C090004)资助

摘　　要：功能核磁共振成像(f MRI)的研究已经发现,人类梭状回包含专门加工面孔的区域,通常被称为梭状回面孔区(FFA).然而,仅依靠f MRI技术本身不能直接说明FFA与面孔加工间存在因果关系.结合f MRI、颅内电极记录、电刺激技术可直接为二者的因果关系提供重要的证据.本研究借助一例难得的颅内置入电极恰好与左侧FFA重叠的癫痫病例系统地考察了左侧FFA的功能属性.当前研究结果显示,左侧FFA的血氧水平依赖反应和电生理反应都表现出较强的面孔选择性;电刺激与左侧FFA重叠的电极不影响真人面孔知觉;电刺激左侧FFA引起面孔形状感知变化.本研究揭示了左侧FFA在面孔精细特征的加工中起着重要的作用,它在功能上可能区别于右侧对应区域.Functional magnetic resonance imaging （fMRI） studies have identified that the human fusiform gyms contains specialized regions for the processing of faces, often labeled as the fusiform face areas （FFA）. However, fMRI, on its own, is a correlative measurement that cannot provide evidence for the causal role of FFA in face processing. Evidence for a causal role of FFA can be acquired by using a multimodal approach that combines fMRI, electrocorticogram, electronic brain stimulation, and behavior. The current study investigated the role of the left FFA in facial information processing by directly recording event-related potentials from the inferior temporal lobes with intracranial electrodes in a patient with suspected right temporal lobe epilepsy. Our results show that, faces induced stronger blood oxygenation level dependent and electrophysiological response at the left FFA compared to other image categories; electrical stimulation through the electrode placed at the left FFA did not produce self-reports of perceptual face distortion; but electrical stimulation to the left FFA did reduce sensitivity to subtle changes in facial contours. These results suggest that the left FFA may play a causal role in the fine processing of facial shape, and may have distinct functions from the corresponding area of the right hemisphere.

关 键 词：电刺激 颅内记录 梭状回面孔区 面孔知觉 精细加工 

分 类 号：R741[医药卫生—神经病学与精神病学]