Orexin-A对癫痫患者认知功能的影响  

Effect of Orexin-A on Cognitive Function of Patients with Epilepsy

作　　者：杨位霞[1] 吴卫文[1] 肖祥之[1] 阚琳 赵君[1] 杨位芳[1,2] 

机构地区：[1]复旦大学附属中山医院青浦分院神经内科,上海201700 [2]山东济宁众和医院,山东济宁272000

出　　处：《中国临床医学》2015年第4期516-518,共3页Chinese Journal of Clinical Medicine

基　　金：上海市卫生和计划生育委员会基金(编号:20124258);山东省自然科学基金资助项目(编号:Y2008C1610)

摘　　要：目的:探讨血清orexin-A在癫痫所致认知功能障碍中的作用。方法:选择80例癫痫患者(癫痫组)和40名健康志愿者(对照组),采用简易精神状态检查(mini-mental state examination,MMSE)量表评价认知功能,采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测空腹静脉血中的orexin-A水平。结果:癫痫组认知障碍的发生率高于对照组,差异有统计学意义(P<0.05)。癫痫伴认知障碍组的orexin-A水平低于癫痫不伴认知障碍组和对照组,差异有统计学意义(P<0.05)。癫痫伴重度认知障碍组orexin-A水平低于癫痫伴中度认知障碍组和癫痫伴轻度认知障碍组,差异有统计学意义(P<0.05)。结论:orexin-A水平降低可能与癫痫患者认知功能的减退有关。Objective：To explore the effect of serum orexin-A on cognitive impairment caused by epilepsy. Methods：The cogni- tive function of 80 epileptic patients and 40 healthy controls was evaluated by mini-mental state examination （MMSE）, while the level of orexiwA in fasting venous blood sample was detected by enzyme linked immunosorbent assay （ELISA）. Results： The incidence rate of cognitive impairment in epileptic group was higher than that in control group, and there was a significant difference （ P〈0. 05）. The level of orexiwA in epileptic patients with cognitive impairment was lower than that in epileptic pa- tients without cognitive impairment and healthy controls, and there was a significant difference （ P〈0. 05）. The level of orex in A in epileptic patients with severe cognitive impairment was lower than that in epileptic patients with mild or moderate cogni tive impairment, and there were significant differences （ P〈0. 05）. Conclusions： The decreasing level of Orexin A may be re- lated to cognitive impairment of epileptic patients.

关 键 词：癫痫 OREXIN-A 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]