健康未成年人群干化学法血清酶水平分析  

Analysis of Serum Enzymes in Healthy Children and Adolescents by Dry Chemical System

作　　者：罗小娟[1] 曹科[1] 马东礼[1] 刘新刚[1] 黄宝兴[1] 陈运生[1] 

机构地区：[1]深圳市儿童医院检验科,广东深圳518038

出　　处：《循证医学》2015年第4期232-236,共5页The Journal of Evidence-Based Medicine

基　　金：深圳市科技局资助项目(201203074);深圳市发改委重点实验室资助项目([2012]866)

摘　　要：目的了解深圳市健康未成年人血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)活性的数据,分析以年龄、性别分组后四种血清酶的差异情况。方法将2 351名3月龄到18周岁健康未成年人分为婴幼儿组、学龄前组、学龄组、青春组,使用干生化分析仪检测四种血清酶,分析各年龄、性别血清酶活性。结果学龄组的AST、ALP、GGT,青春组的ALT、AST、ALP、GGT男、女组间差异均有统计学意义(P值均<0.05),除学龄组ALP女童高于男童外,其余均为男童高于女童,其余各组无性别差异(P值均>0.05)。随着年龄的增长,各项目呈现不同的变化趋势,婴幼儿组与学龄组的ALP、学龄前组与学龄组的ALT差异无统计学意义(P值均>0.05),其余各年龄组间差异均有统计学意义(P值均<0.05),不同年龄组血清酶水平存在差异。结论未成年人血清酶活性水平具有性别差异及年龄趋势性变化,应建立相适应的参考区间。Objective To analyze the level of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase（ALP）, gamma glutamyhransferase（GGT） among healthy children and adolescents, and compare the differences between genders and ages. Methods A total of 2 351 healthy children and adolescents aged from 3 months to 18 years were divided into 4 groups： infant group, pre-school group, school age group and youth group. The serum enzymes in venous blood were detected by dry chemical system, and data were analyzed by statistical methods between different ages and genders. Results Except the ALP of school age group in girls was significantly higher than that in boys （P〈0.05）, the AST, GGT of school age group and the ALT, AST, ALP, GGT of youth group in boys was significantly higher than that in girls （P〈0.05）. The serum enzymes showed significant differences in different age groups. The trend of 4 enzymes increase or decline with increasing age （P〈0.05）, but ALP showed no significant difference between infant and school age group, ALT showed no significant difference between pre-school and school age group （P〉0.05）. We should set up different reference intervals according to the different age group. Conclusion The serum enzymes have gender differences and significantly associated with the change of age in healthy children and adolescents, and the laboratory shall establish a corresponding reference intervals.

关 键 词：血清酶 干化学法 儿童 青少年 

分 类 号：R446.11[医药卫生—诊断学]