自动乳腺全容积扫查对乳腺癌预后评估的价值  

Value of automated breast volume scanner for evaluating prognosis of breast cancer

作　　者：金叶[1] 李凤华[1] 王琳[1] 杜晶[1] 万财凤[1] 

机构地区：[1]上海交通大学医学院附属仁济医院超声科,上海200127

出　　处：《上海交通大学学报（医学版）》2015年第9期1369-1373,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的研究自动乳腺全容积扫查(ABVS)在乳腺癌预后评估中的价值。方法分析81例乳腺癌ABVS图像,观察病灶的边缘、生长方式、后方回声、钙化及"汇聚征"等形态学表现,并与乳腺癌的预后指标包括病理级别、淋巴结、雌激素受体(ER)、孕激素受体(PR)及c-erb B-2等进行相关性分析。结果 51.85%(42/81)伴毛刺征,其中11.90%(5/42)的毛刺仅在冠状面察见,毛刺征组的ER/PR阳性率高、c-erb B-2阳性率低(均P<0.01);30.86%(25/81)有后方回声增强,多见于ER/PR阴性、c-erb B-2阳性的乳腺癌(均P<0.01);53.09%(43/81)伴微钙化,并与c-erb B-2阳性表达有关(P=0.018);45.68%(37/81)有"汇聚征",常为低级别(Ⅰ/Ⅱ级)(P=0.023)、ER/PR阳性、c-erb B-2阴性(均P<0.01)的乳腺癌。结论 ABVS通过形态特征特别是"汇聚征"能反映肿瘤的预后指标,能对乳腺癌进行有效的在体预后评估。Objective To investigate the value of automated breast volume scanner（ABVS） for evaluating the prognosis of breast cancer.Methods ABVS images of 81 cases of breast cancer were analyzed.Morphological manifestations such as the lesion margin,growth orientation,posterior echo,calcification status,and retraction phenomenon were observed and the correlation with prognostic factors of breast cancer such as pathological grade,lymph node,estrogen receptor（ER）,progesterone receptor（PR）,and human epidermal growth factor receptor 2（c-erbB-2） was analyzed.Results Among 81 cases,42（51.85%） had spiculate margin,and only5 of them（11.90%） were found on the coronal plan.For patients with spiculate margin,the ER/PR positive rate was high（P〈0.001） and c-erbB-2 positive rate was low（P〈0.001）.Among 81 cases,25（30.86%） had posterior enhancement and most of them were breast cancer patients with negative ER/PR and positive c-erbB-2（P〈0.001）.Among 81 cases,43（53.09%） had microcalcification and was relevant to positive expression of cerbB-2（P=0.018）.Among 81 cases,37（45.68%） had retraction phenomenon and most of them were breast cancer patients with low grades（grade Ⅰ/Ⅱ）（P = 0.023）,positive ER/PR,and negative c-erbB-2（P〈0.001）.Conclusion ABVS can reflect prognostic factors of breast cancer based on morphological features,especially retraction phenomenon,and can efficiently evaluate the prognosis of breast cancer.

关 键 词：自动乳腺全容积扫查 乳腺癌 汇聚征 预后因子 

分 类 号：R737.9[医药卫生—肿瘤]