天然多糖调控p53基因表达的研究进展  

Research Progress of Natural Polysaccharides on the p53 Gene Expression

作　　者：陈美琴[1,2] 吴光杰[1,2] 李玉萍[1,2] 

机构地区：[1]江西科技师范大学生命科学学院 [2]江西省生物加工过程重点实验室,南昌330013

出　　处：《天然产物研究与开发》2015年第9期1687-1691,1642,共6页Natural Product Research and Development

基　　金：国家自然科学基金(31360376);江西省自然科学基金(20132BAB205091);江西省教育厅科技(GJJ13579)

摘　　要：天然多糖因其显著的抗肿瘤活性和毒副作用小,成为目前抗肿瘤药物筛选的研究热点。其抗肿瘤作用的机理涉及增强机体免疫细胞的活性、改变细胞膜流动性、诱导肿瘤细胞周期阻滞或凋亡、抑制肿瘤细胞的核酸和蛋白质合成、调控肿瘤基因的表达等方面。本文对近几年来国内外有关天然多糖通过调控肿瘤抑制基因p53达到抗肿瘤作用的研究进行综述,为进一步研究与开发利用天然多糖抗肿瘤提供参考依据。Natural polysaceharides were attracted more attention on antitumor drug screening for its antitumor effect and low side effect. The antitumor mechanism of natural polysaccharides were refer to enhance the immune activity, change cell membrane fluidity ,induce tumor cell cycle arrest or apoptosis ,inhibit nucleic acid and protein synthesis ,regulate the expression of tumor genes, etc. This article described the research progress of antitumor mechanism of natural polysaccha- rides through the regulation of p53 gene at home and abroad in recent years,which provided some references for future development and utilization of natural polysaccharides.

关 键 词：天然多糖 P53基因 肿瘤 

分 类 号：R730.1[医药卫生—肿瘤]