胸段食管鳞癌患者喉返神经旁淋巴结清扫术后预后的影响因素分析  

Influencing Factors for the Prognosis of Patients With Thoracic Esophageal Squamous Cell Carcinoma Undergoing Lymphadenectomy Along the Recurrent Laryngeal Nerve

作　　者：张卫民[1] 丁小云[1] 崔启辰[1] 瞿伟丰[1] 

机构地区：[1]江苏省无锡市第三人民医院胸心外科,214041

出　　处：《中国全科医学》2015年第25期3062-3064,3068,共4页Chinese General Practice

摘　　要：目的探讨胸段食管鳞癌患者喉返神经旁淋巴结清扫术后预后的影响因素。方法选取2010年1月—2011年12月在无锡市第三人民医院就诊且接受喉返神经旁淋巴结清扫术的胸段食管鳞癌患者108例,以其中完成随访要求的101例患者为研究对象。根据患者术后3年的预后情况,将其分为生存组(n=76)和死亡组(n=25)。记录并比较两组患者临床资料,包括性别、年龄、吸烟史、肿瘤部位、病理分期、分化程度、淋巴结转移数目及术后治疗,探讨影响其预后的因素。结果生存组和死亡组患者的肿瘤部位、术后病理(PT)分期、美国癌症联合会(AJCC)分期、分化程度及淋巴结转移数目比较,差异均有统计学意义(P<0.05),而性别、平均年龄、吸烟史及术后治疗比较,差异无统计学意义(P>0.05)。Cox回归模型分析结果显示,肿瘤部位、PT分期、AJCC分期及分化程度对胸段食管鳞癌患者喉返神经旁淋巴结清扫术后预后的影响有统计学意义(P<0.05)。结论肿瘤部位、PT分期、AJCC分期及分化程度是胸段食管鳞癌患者喉返神经旁淋巴结清扫术后预后的影响因素。Objective To investigate influencing factors for the prognosis of patients with thoracic esophageal squamous cell carcinoma undergoing lymphadenectomy along the recurrent laryngeal nerve. Methods From January 2010 to December 2011,we selected 108 patients with thoracic esophageal squamous cell carcinoma who received treatment and underwent lymphadenectomy along the recurrent laryngeal nerve in the Third People＇s Hospital of Wuxi. Among them,we enrolled 101 patients who met the requirements of follow - up. According to 3 - year prognosis after surgeries,the subjects were divided into two groups：survival group（ n = 76）and death group（ n = 25）. The clinical data of the two groups were recorded, including gender, age, smoking history, tumor site, pathological stage, differentiated degree, the amount of lymphatic metastasis and postoperative treatment. Influencing factors for prognosis were investigated. Results The survival group and death group were significantly different（P 〈 0. 05）in tumor site,postoperative pathological stage,AJCC stage,differentiated degree and the amount of lymphatic metastasis,while the two groups were not significantly different（ P 〉 0. 05）in gender,average age,smoking history and postoperative treatment. Cox multivariate analysis showed that tumor site,postoperative pathological stage,AJCC stage and differentiated degree had significant influence on the prognosis of patients with thoracic esophageal squamous cell carcinoma undergoing lymphadenectomy along the recurrent laryngeal nerve（ P 〈 0. 05）. Conclusion Tumor site,postoperative pathological stage,AJCC stage and differentiated degree are influencing factors for the prognosis of patients with thoracic esophageal squamous cell carcinoma undergoing lymphadenectomy along the recurrent laryngeal nerve.

关 键 词：食管肿瘤 淋巴结切除术 预后 影响因素分析 

分 类 号：R735.1[医药卫生—肿瘤]