含氟牙膏和含氟涂料对脱矿釉面再矿化作用的实验研究  

Efficacy of fluoride toothpaste and fluoride varnish on enamel remineralization in vitro

作　　者：许浩坤 姚博文 易飞舟[2] 王胜朝 

机构地区：[1]军事口腔医学国家重点实验室,陕西省口腔医学重点实验室,第四军医大学口腔医院口腔预防科,陕西西安710032 [2]解放军第105医院,安徽合肥230031

出　　处：《牙体牙髓牙周病学杂志》2015年第9期534-537,共4页Chinese Journal of Conservative Dentistry

基　　金：国家自然科学基金(81170947)部分资助

摘　　要：目的:分析含氟牙膏与含氟涂料对脱矿釉面再矿化的作用。方法:用离体牛恒切牙制备釉质片,酸蚀脱矿后随机分为3组(n=9):A组为对照组,用生理盐水处理(2次/日),B组用含氟牙膏规律处理(2次/日),C组用含氟涂料1次处理;各组标本置于人工唾液模拟口腔孵育2周。分别于酸蚀前、后以及分组处理2周后,用显微硬度测量仪测定釉面显微硬度,SEM观察釉面形态,图像分析釉面微孔隙面积;对数据进行统计学分析。结果:酸蚀后釉面显微硬度较酸蚀前显著降低(P<0.05);再矿化2周后,A组釉面显微硬度提高不明显(P>0.05);B、C组显微硬度明显提高(P<0.05)。再矿化处理2周后,A组釉面有少许矿物沉积,B、C组釉面均有明显的矿物沉积。再矿化处理2周后,A组微孔隙面积减小不明显(P>0.05);B、C组微孔隙面积明显减小(P<0.05);B、C组间差异不明显(P>0.05)。结论:含氟牙膏和含氟涂料对脱矿釉面再矿化均有促进作用,规律自用含氟牙膏可能达到与医用含氟涂料类似效果。AIM： To analyze the effects of fluoride toothpaste and fluoride vamish on enamel remineraliza- tion in vitro. METHODS ： Enamel specimens of extracted bovine teeth were made and demineralized by 370 g/L phos- phoric acid. Specimens were randomly divided into 3 groups （n = 9）. The samples in group A, B and C were treated by normal saline（ twice a day）, a fluoride toothpaste（ twice a day） and fluoride varnish（ only once） respectively. Speci- mens were incubated in artificial saliva for 2 weeks. Micro - hardness evaluation, SEM observation and image analysis were performed before and after demineralization and after 2 - week - remineralization. RESULTS ： Enamel hardness decreased in all groups after demineralization （ P 〈 0.05 ）. 2 weeks after remineralization, micro - hardness value in group A increased slightly （ P 〉 0.05 ）, while it increased significantly in group B and C （ P 〈 0.05 ）. 2 weeks after remineralization, a large amount of remineralization deposits were found on the endamal surface in group B and C, but only a few was found in Group A. After remineralization the micro - hole area in group A decreased slightly （ P 〉 0.05 ）, but remarkably decreased in group B and C （P 〈 0.05）. There was no difference between group B and C （ P 〉 0.05）. CONCLUSION ： Both fluoride toothpaste and fluoride varnish have positive effects on remineralizaion of enamel in vitro.

关 键 词：釉质 再矿化 含氟牙膏 含氟涂料 

分 类 号：R780.1[医药卫生—口腔医学]