抗菌药物不同给药途径对金双歧预防抗生素相关性腹泻的影响研究  

Influence of antibacterial drug delivery system on preventive effct of Golden Bifid on antibiotic associated diarrhea

作　　者：柴建华[1] 舒红文[1] 常洪美[1] 李炼[1] 余霞辉[1] 邓毅[1] 罗杨[1] 

机构地区：[1]崇州市人民医院,四川崇州611230

出　　处：《中国微生态学杂志》2015年第9期1044-1046,共3页Chinese Journal of Microecology

基　　金：2013年成都市科技惠民计划项目(2013-HM01-3-00004-SF);成都市医学重点专科建设资助项目

摘　　要：目的研究抗菌药物不同给药途径对金双歧预防急性化脓性扁桃体炎患儿抗生素相关性腹泻的影响,为临床合理利用金双歧辅助治疗提供依据。方法选取崇州市人民医院2013年1月至2014年7月开展的"金双歧辅助治疗儿童扁桃体炎的疗效研究"科研项目中试验组患儿85例,观察其在住院期间(静脉使用抗菌药物期间)和出院后期间(口服抗菌药物期间)抗生素相关性腹泻的发生,两期间均口服金双歧预防抗生素相关性腹泻。结果静脉使用抗菌药物期间8例患儿发生抗生素相关性腹泻,发生率为9.41%;口服抗菌药物期间1例患儿发生抗生素相关性腹泻,发生率为1.18%。两期间比较差异具有统计学意义(χ2=5.749,P=0.016)。结论静脉使用抗菌药物比口服抗菌药物对金双歧的抑制和杀灭作用影响大,使金双歧预防继发性腹泻的能力减弱或消失。Objective To explore the impact of different method of antimicrobial drug delivery on the results of Golden Bifid（ Jin Shuang Qi） preventing antibiotic associated diarrhea in children with acute suppurative tonsillitis,and provide basis for clinical rational use of Golden Bifid as the adjuvant treatment. Methods 85 children enrolled in the project Golden Bifid as Adjuvant Therapy for Tonsillitis in Children from January 2013 to July 2014 were included and observed for the incidence rate of antibiotic associated diarrhea during their hospitalization（ intravenous administration of antibacterial drugs） and after discharge（ oral administration of antimicrobial drugs）while accepting oral Golden Bifid to prevent antibiotic associated diarrhea. Results 8 cases（ 9. 41%） of antibiotic associated diarrhea during intravenous use of antibacterial drugs vursus 1 case（ 1. 18%） during oral administration were recorded; the difference was statistically significant（ χ^2= 5. 749,P = 0. 016）. Conclusion Intravenous use of antibacterial drugs,compared to oral administration,can inhibit and reduce more significantly the preventive effect of Golden Bifid on antibiotic associated diarrhea.

关 键 词：抗菌药物、金双歧 化脓性扁桃体炎 抗生素相关性腹泻 

分 类 号：R574[医药卫生—消化系统]