大鼠海马认知障碍对糖脂代谢的影响及其与胃肠运动的关系  

Effects of cognitive impairment in hippocampus on glucose and lipid metabolism and its relations with gastrointestinal motility in rats

作　　者：叶琳[1] 杜森[1] 朱琳[1] 夏春波[1] 

机构地区：[1]广西壮族自治区桂林医学院解剖教研室,541004

出　　处：《实用医学杂志》2015年第17期2789-2792,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81260137)

摘　　要：目的:探索海马认知障碍对糖脂代谢的影响及其与胃肠运动的关系。方法:大鼠海马注射Aβ1-42构建认知障碍模型,检测血糖血脂水平,B超、推墨实验检测胃肠运动变化,TUNEL法检测海马神经元凋亡。结果:实验组FPG、TG、TC、LDL分别为(7.92±0.29)mmol/L、(2.24±0.12)mmol/L、(4.67±0.12)mmol/L、(2.41±0.12)mmol/L,均明显高于假手术组和对照组(P<0.05)。实验组单位时间肠蠕动次数、小肠推进比、胃排空率分别为(2.13±0.83)次、(44.35±7.53)%、(57.60±7.82)%,均明显低于假手术组和对照组(P<0.05)。实验组海马神经元凋亡指数为(64.98±3.70)%,明显高于其他两组(P<0.05)。结论:大鼠海马认知障碍可能会引起血糖血脂升高,其机制可能与海马神经元凋亡和胃肠运动障碍有关。Objective To investigate the effects of cognitive impairment in hippocampus on glucose and lipid metabolism, and its relations with gastrointestinal motility. Methods The Aβ1-42 was injected into thehippocampus of rats. Levels of glucose and lipid were detected. The changes of gastrointestinal motility were detected by the type-B ultrasonic and the ink-pushing experiments. Hippocampal neurons apoptosis was detected by the TUNEL assay. Results In the experimental group, FPG, TG, TC, LDL were （7.92 ± 0.29） mmol/L, （2.24 ±0.12） mmol/L, （4.67±0.12） mmol/L, （2.41± 0.12） mmol/L, respectively, with significant differences among these three groups （P 〈 0.05）. Compared with the sham group and the control group, the number of bowel movements per unit time （2.13 ± 0.83） times, gastric emptying rate （44.35± 7.53） % and the small intestinal propulsion rate （57.60 ±7.82）% in the experimental group were significantly decreased （P 〈 0.05）. The experimental hippocampal neuronal apoptosis index was an average of （64.98± 3.70）%, which was significantly higher than that in the sham group and the control group （P 〈 0.05）. Conclusion Hippocampal cognitive impairment can elevate the blood lipid level, which may be associated with the hippocampal neuronal apoptosis and the gastrointestinal motility disorders.

关 键 词：认知功能障碍 海马 糖脂代谢 胃肠运动 

分 类 号：R749.16[医药卫生—神经病学与精神病学]