复合乳酸菌治疗慢性阻塞性肺疾病急性加重的价值  

Effects of lactobacillus complex capsules in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：李健[1] 陈锦平[1] 彭玲[1] 刘大鹰[1] 

机构地区：[1]广西壮族自治区柳州市柳铁中心医院呼吸内科,545007

出　　处：《实用医学杂志》2015年第17期2886-2889,共4页The Journal of Practical Medicine

基　　金：广西卫生厅自筹经费课题项目(编号:Z2011235);柳州市科学研究与技术开发计划课题(编号:2013J030413)

摘　　要：目的:探索复合乳酸菌胶囊治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的价值。方法:100例AECOPD患者分为常规治疗组(对照组)50例和常规+复合乳酸菌胶囊治疗组(治疗组)50例。记录2组住院天数、治疗前、治疗后7 d动脉血气、呼吸困难评分、肺功能、炎症指标、纳差评分、腹泻例数、真菌感染例数、死亡例数、呼吸频率和复合乳酸菌不良反应。结果:治疗后,治疗组和对照组血白细胞计数(white blood cell,WBC)分别为(7.4±2.0)×109/L和(8.8±2.6)×109/L(t=2.29,P=0.026);治疗组和对照组中性粒细胞比例分别为(67±7)%和(73±13)%(t=2.09,P=0.042);治疗组和对照组纳差评分≤2分的率分别为100%和84%(χ2=6.66,P=0.010)。2组治疗后其余观察指标差异无显著性(P>0.05)。治疗组未见皮疹、腹泻等。结论:AECOPD患者口服复合乳酸菌胶囊有抗感染、改善食欲的作用,安全性好。Objective To observe the effects of lactobacillus complex capsules in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods A hundred AECOPD patients weredivided into 2 groups： the therapy group（n = 50） with conventional and lactobacillus complex capsules therapy, and the control group with conventional therapy only. Parameters before and after therapy were compared, which included length of hospital stay, arterial blood gases, dyspnea grade, respiratory function test, markers of inflammation, anorexia score, diarrhea, fungi infection, breathing rate, death rate and side-effects of lactobacillus complex capsules. Results After 7 days of treatment, the blood leukocyte count and neutrophil ratio in the therapy group were lower than that of the control group （P 〈 0.05）. The rate of anorexia score ≤ 2 in the therapy group was higher than that of the control group （P 〈 0.05）. There were no differences in the rest parameters among the two groups（P 〉 0.05）. There were no slde-effects, such as skin rash and diarrhea, to be observed in the therapy group. Conclusion Oral lactobacillus complex capsule can be safe, anti-infective and improve appetite in oatients with AECOPD.

关 键 词：肺疾病 慢性阻塞性 治疗 微生态制剂 乳酸菌 

分 类 号：R563.9[医药卫生—呼吸系统]