异基因造血干细胞移植后偏肺病毒合并巨细胞病毒感染1例  

Human metapneumovirus and cytomegalovirus coinfection in an ailogeneic hematopoietic stem cell transplant recipient one case

作　　者：陈婷婷[1] 叶枫[1] 杨子峰[1] 

机构地区：[1]广州医科大学附属第一医院广州呼吸疾病研究所呼吸疾病国家重点实验室呼吸疾病国家临床医学研究中心,510230

出　　处：《国际呼吸杂志》2015年第18期1394-1396,共3页International Journal of Respiration

基　　金：国家科技支持计划（2012BA105B01）;广东省省级科技计划（20138020224006）;广州市科技计划项目一广州市健康医疗协同创新重大专项（201400000002）

摘　　要：目的报道1例急性非淋巴细胞白血病患者异基因造血干细胞移植后发生巨细胞病毒（cMV）合并偏肺病毒（hMPV）感染病例，并监测其hMPV排毒时间。方法定期采集患者咽拭子和痰样本，采用实时荧光定量聚合酶链反应的方法测定样本中hMPV的拷贝数。结果该患者的咽拭子和痰中hMPV持续阳性至发病后第41天。结论免疫功能低下患者感染hMPV可长期无症状排毒，临床医生需要给予动态监测，并做好预防院内感染的措施。Objective To report the occurrence of lower respiratory tract disease associated with cytomegalovirus and hMPVcoinfection in a patient after allogeneic hematopoietic stem cell transplantation （HSCT） for acute non-lymphocytic leukemia, and to monitor the shedding time of hMPV. Methods Patient＇s oropharyngeal swab and sputum samples periodically were collected, hMPV copies in these sampes were determined by real-time polymerase chain reaction. Results Repeat oropharyngeal swab and sputum samples was positive for hMPV until 41th day after onset. Conclusions Immunocompromised patients infected with hMPV will show as prolong viral shedding with asymptomatic and the clinician must pay more attention on immunocompromised patients for viral shedding, and prevent cross infection in the ward.

关 键 词：异基因造血干细胞移植 偏肺病毒 巨细胞病毒 

分 类 号：R-02[医药卫生]