2000~2014年中医药干预化疗所致消化道毒性反应临床试验的方法学质量评价  

Methodological quality assessment of clinical trials on Chinese medicine interventional chemotherapy induced gastrointestinal toxic reactions during 2000-2014

作　　者：黄惠榕[1] 陈梅[2] 

机构地区：[1]福建中医药大学附属人民医院护理部,福州350004 [2]福建中医药大学附属人民医院肿瘤科,福州350004

出　　处：《重庆医学》2015年第26期3661-3663,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81403446)

摘　　要：目的评价2000~2014年中国中医药干预化疗致消化道毒性反应临床试验的方法学质量。方法计算机检索知网、万方、维普、中国生物医学文献数据库及中国中医药数据库（2000年1月至2014年12月）,并辅以手工检索。采用Cochrane偏倚风险评估表对纳入的随机对照试验、半随机对照试验进行方法学质量评价。结果最终筛选研究291篇,符合Cochrane偏倚风险评估表＂低风险＂标准至少一条的随机对照试验及半随机对照试验仅76个,总体方法学质量欠佳。结论近14年来,中医药疗法干预化疗致消化道毒性反应的临床试验发表呈逐年上升趋势,但总体研究设计存在缺陷。Objective To evaluate the methodological quality of clinical trials on Chinese medicine interventional chemothera- py induced gastrointestinal toxic reactions from 2000 to 2014.Methods The randomized controlled trials（RCT） and semi-RCT on Chinese medicine interventional chemotherapy induced gastrointestinal toxic reactions were retrieved from the China National Knowledge Infrastructure （CNKI）, Wanfang databases, VIP, China Biology Medicine Database （CBM） and Traditional Chinese Medicine （TCM） database by computer and supplemented by the manual retrieval （January 2000 to December 2014）. The methodo- logical quality assessment on the included RCT and semi-RCT was conducted by using the Cochrane risk assessment table of bias. Results 291 articles were finally screened out,only 76 of RCT and semi-RCT were conformed to the at least one of low risk stand- ards of Cochrane risk assessment table of bias. Therefore the total methodological quality was not good enough. Conclusion The publishing of clinical trials on Chinese medicine interventional chemotherapy induced gastrointestinal toxic reactions shows the in- creasing trend year by year during the past 14 years. However,the different defects exist in the overall trial design.

关 键 词：抗肿瘤联合化疗方案 胃肠道 毒性作用 临床试验 质量评价 

分 类 号：R730.5[医药卫生—肿瘤]