血清YKL-40、MCP-1水平与乳腺癌患者转移和预后的关系  

Relationship of the level of YKL-40 and MCP-1 with the metastasis and prognosis of breast cancer.

作　　者：唐琴[1] 丁克保[1] 施开德[1] 朱际彪 鲁斌[1] 吕刚[1] 

机构地区：[1]安徽医科大学附属巢湖医院甲乳外科,安徽巢湖238000

出　　处：《安徽医药》2015年第9期1722-1725,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨人软骨糖蛋白39(YKL-40)和单核细胞趋化蛋白1(MCP-1)水平与乳腺癌转移和预后的相关性。方法采用酶联免疫吸附法分别检测64例乳腺癌和47例健康人群血清YKL-40和MCP-1水平,分析两项指标与乳腺癌临床病理的相关性以及与生存期和预后关系。结果乳腺癌组患者YKL-40和MCP-1平均水平分别为(286.3±96.7)ng·L-1和(171.2±105.4)μg·L-1,明显高于健康人群(164.1±70.9)ng·L-1和(118.5±77.6)μg·L-1(P<0.01);YKL-40升高与淋巴结转移有关(P<0.05),而MCP-1升高与有无淋巴结转移和TNM分期有关(P<0.05)。Kaplan-Meier分析显示YKL-40和MCP-1升高组3年生存率分别为46.75%和53.12%,而YKL-40和MCP-1正常组3年生存率分别为76.56%和81.25%(P<0.05)。Cox风险回归分析显示YKL-40和MCP-1均是判断乳腺癌预后的独立危险因素,而YKL-40升高对预后不良的相对危险度更高(RR=2.87 vs 2.25)。结论血清YKL-40和MCP-1升高的乳腺癌患者淋巴结转移风险高。测定血清YKL-40和MCP-1水平,有助于判断乳癌患者预后。Objective To investigate the relationship between the serum cartilage glycoprotein 39 （YKL-40） and monocyte chemotactic protein-1 （MCP-1） with metastasis and prognosis in breast cancer patients.Methods The enzyme-linked immunosorbent method was carried out to detect the levels of serum YKL-40 and MCP-1 in 64 cases of breast cancer patients and 47 healthy people as control group.Analysis the relationship between indicators and clinical pathologic,survival and prognosis of breast cancer patients.Results The average value of YKL-40 and MCP-1 in Breast cancer patients were respectively （286.3 ±96.7） ng· L-1 and （171.2 ±105.4）μg· L -1,significantly higher than that of healthy people（164.1 ±70.9）ng· L -1and （118.5 ±77.6）μg· L -1 （P 〈0.01）.The e-valuated of YKL-40 was relate to lymph node metastasis （P〈0.05）,while the promotional of MCP-1 was associated with presence of lymph node metastasis and TNM stages （P〈0.05）.Kaplan-Meier analysis showed the 3 year survival rate in YKL-40 and MCP-1evaluated group were 46.75% and 53.12% respectively, has significant difference with the normal YKL-40 and MCP-1 groups （76.56%and 81.25%,respectively ）（P〈0.05）.Cox regression analysis showed YKL-40 and MCP-1 were independent risk factors of prognosis of breast cancer,but the relative risk of YKL-40 was even higher than MCP-1（RR =2.87 vs 2.25）.Conclusion The breast cancer patients with elevated serum YKL-40 and MCP-1 have high risk of lymph node metastasis.It is helpful to judge the prog-nosis of patients with breast cancer by detect the serum levels of YKL-40 and MCP-1.

关 键 词：人软骨糖蛋白39(YKL-40) 单核细胞趋化蛋白1(MCP-1) 乳腺癌 转移 预后 

分 类 号：R737.9[医药卫生—肿瘤]