安非他酮对康复期酒依赖患者疗效的对照研究  

A control study of effect of bupropion for patients with alcohol dependence in rehabilitation

作　　者：孙辉[1] 

机构地区：[1]邹平县精神卫生中心,山东邹平256218

出　　处：《精神医学杂志》2015年第4期290-292,共3页Journal of Psychiatry

摘　　要：目的探讨安非他酮在酒依赖患者康复期治疗中的效果。方法将93例康复期酒依赖患者随机分为研究组(48例)和对照组(45例),两组患者均维持原有治疗方案,研究组在此基础上加用安非他酮治疗,共3个月。在基线时及治疗后第3个月末接受饮酒问卷(ADS)、密西根酒精调查表(MAST)、抑郁自评量表(SDS)、焦虑自评量(SAS)评定。结果治疗后第3个月末对照组ADS、MAST、SDS以及SAS评分高于基线时(P<0.01),治疗后第3个月末研究组ADS、MAST、SDS及SAS评分低于对照组(P<0.01);治疗后第3个月末研究组的复饮率低于对照组(P<0.01)。结论安非他酮可有效控制康复期酒依赖患者的酒精渴求程度,改善抑郁焦虑症状,降低复饮率。Objective To explore the effect of bupropion for patients with alcohol dependence in rehabilitation stage. Methods 93patientswithalcoholdependenceinrehabilitationwererandomlydividedintostudygroup（48cases）treatedwith bupropion combined with existing treatment and control group （ 45 cases ） treated with existing treatment for 3 months.All patients were assessed with Alcohol Drinking Scale （ ADS ） , Michigan Alcoholism Screening Test （ MAST ） , Self-rating Depression Scale （ SDS） and Self-rating Anxiety Scale （ SAS） at baseline and at the end of the treatment.Results At the end of the treatment, scores of ADS, MAST, SDS and SAS in control group were significantly higher than those at baseline （ P〈0.01）.Scores of ADS, MAST, SDS and SAS in study group were significantly lower than those in control group at the end of the treatment （P〈0.01）.The re-drinking rate in study group was significantly lower than that in control group at the endpoint （P〈0.01）.Conclusion For patients with alcohol dependence in rehabilitation stage, bupropion is effective in reducing drinking desire, improving depressive and anxiety symptoms, reducing the re-drinking rate.

关 键 词：安非他酮 酒依赖 抑郁 焦虑 复饮 

分 类 号：R749.62[医药卫生—神经病学与精神病学]