HSP90α和IGF-1R在胰腺癌组织中的表达及临床意义  

作　　者：潘超[1] 杨士勇[1] 殷少华[1] 戴树龙[1] 黄冠[1] 周琎[1] 

机构地区：[1]南京医科大学附属南京医院普外科,210006

出　　处：《浙江临床医学》2015年第10期1663-1665,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨热休克蛋白90α（HSP90α）和胰岛素样生长因子-1受体（IGF-1R）在胰腺癌中的表达及临床病理资料间的联系,分析两者在胰腺癌发生、发展中的作用机制.方法 免疫组化方法检测胰腺癌标本中HSP90α、IGF-1R在癌组织及癌旁组织中的表达情况,结合临床病理资料进行分析.结果 胰腺癌组织中HSP90α、IGF-1R的阳性表达率分别为72.5％（29/40）、70％（30/40）,显著高于癌旁组织17.5％（7/40）、20％（10/40）;HSP90α、IGF-1R袁达与肿瘤组织分化程度、淋巴结转移、肿瘤TNM分期相关（P＜0.05）,两者间的表达也呈正相关（r=0.0.808,P＜0.05）.结论 HSP90α、IGF-1R在胰腺癌组织中高表达、正相关,两者参与到胰腺肿瘤的发生、发展过程,存在共同作用的机制促进肿瘤的侵袭、转移变化.联合检测HSP90α、IGF-1R可作为胰腺癌预后判断的指标,也可以作为胰腺癌药物治疗的靶点进行研究.Objective To explore the relationship of Heat shock protein 90 α（ HSP90α ） and Insulin-like growth factor-1 receptor （ IGF- 1R ） on expression level and clinicopathologic data in pancreatic cancer, and analyze the mechanism in initiation, development of pancreatic cancer. methods The expression of HSP90α and IGF-1R between tumor tissues and adjacent mucosas were detected by immunohistochemistry, in addition, clinicopathologic data had been analyzed. Result In pancreatic cancer tissues, The positive expression rate of HSP90 α and IGF-1R were 72.5% （ 29/40 ） , 70% （ 30/40 ） ; significantly higher than the adjacent normal pancreatic tissues 17.5% （ 7/40 ） , 20% （ 10/40 ） （ P〈0.05 ） .Both of organization differentiation and lymph node metastasis and clinical stage were correlative （P〈0.05） .The expression of HSP90 α and IGF-1R were positive correlation （ r=0.808, P〈0.05 ） . Conclusions HSP90 α and IGF-1R were highly expressed in pancreatic cancer tissues, and both expression had positive correlation , Both involved in the process ofpancreatic tmnor occurrence, development, and has the common mechanism to promote tumor invasion, metastasis changes. The combined detection of HSP90 α, IGF-1R can be used as a prognostic indicator for pancreatic cancer, can also be used as a target for pancreatic cancer drug treatment were studied.

关 键 词：胰腺癌 免疫组化学 热休克蛋白90Α 胰岛素样生长因子-1受体 

分 类 号：R735.7[医药卫生—肿瘤]