12例原发性肺淋巴上皮瘤样癌的临床病理分析  

Clinicopathologic analysis of 12 cases with primary lymphoepithelioma-like carcinoma of the lung

作　　者：王康玮 魏树全[2] 陈少红[2] 刘国荣[2] 唐昭亮 史文利 杜洪[2] 

机构地区：[1]广州市南沙中心医院,广州511457 [2]广州市第一人民医院,广州510180

出　　处：《广州医药》2015年第5期9-11,共3页Guangzhou Medical Journal

摘　　要：目的分析总结12例原发性肺淋巴上皮瘤样癌(LELC)的临床病理特点。方法回顾性分析12例肺LELC患者的临床病理资料。结果 12例肺LELC患者的组织学标本中,肿瘤细胞均明显表达HCK,原位杂交EBER阳性率为91.7%。全组中位生存期61.3个月,2年和5年生存率分别为84.6%和57.7%。结论原发性肺LELC临床罕见,发病可能与EB病毒感染有关,经及时治疗有较好的预后。Objective To investigate the pathological and clinical significance of 12 cases with primary Lymphoepithe-lioma-like carcinoma of the lung （LELC）. Methods Retrospectively detectded and analyzed the clincalpathological feature of 12 cases of LELC of the lung. Results Histological study showed that tumor cells were significantly expressed HCK by im-munohistochemistry staining and showed out 91.7% positive rate of EBER by situ hybridization.In this series,the median sur-vival time was 61.3 months.The overall 2 and 5 year survival rates of the 12 cases were 84.6% and 57.7%. Conclusion Pulmonary LELC is very rare.It may be associated with Epstein-Barr virus infection,and has a batter prognosis after therapy.

关 键 词：肺淋巴上皮瘤样癌 肺癌 临床病理特征 回顾性分析 

分 类 号：R734.2[医药卫生—肿瘤]