慢性精神分裂症与氧化应激关系的初步研究  

Preliminary study of the relationship between chronic schizophrenia and oxidative stress

作　　者：李丹[1] 徐阿红[2] 易正辉[1] 汪作为[2] 薛志强[2] 林萍[1] 

机构地区：[1]上海市精神卫生中心检验科,上海200030 [2]上海市虹口区精神卫生中心检验科,上海200083

出　　处：《国际检验医学杂志》2015年第18期2650-2651,共2页International Journal of Laboratory Medicine

基　　金：上海市虹口区卫生系统科研立项课题(虹卫1302-06号)

摘　　要：目的通过分析丙二醛(MDA)和超氧化物歧化酶(SOD)水平变化初步探讨精神分裂症是否存在氧化应激的过程,并分析年龄对MDA和SOD水平的影响。方法采用酶联免疫吸附试验(ELISA)分别检测精神分裂症组和健康对照组血清MDA和SOD水平,采用t检验进行统计分析。结果与健康对照组比较,精神分裂症组患者血清MDA水平升高、SOD水平降低,差异均有统计学意义(P<0.05);且相同年龄段两组MDA、SOD水平比较差异均有统计学意义(P<0.05);同时,分别比较两组不同年龄段血清MDA、SOD水平发现,精神分裂症组及健康对照组大于或等于50岁者与小于50岁者血清MDA、SOD水平差异均无统计学意义(P<0.05)。结论精神分裂症患者体内存在着氧化应激过程,且氧化应激可能参与精神分裂症的发生、发展过程,年龄与精神分裂症并无明显相关性。Objective To explore whether the process of oxidative stress exists in schizophrenia through analyzing changes of levels of malondialdehyde（MDA） and superoxide dismutase（SOD） ,and analyse the influence of age on SOD and MDA .Methods Serum levels of MDA and SOD in the schizophrenia group and healthy control group were detected by using enzyme‐linked immu‐nosorbent assay（ELISA） and were statistically analysed by using t test .Results Compared with the healthy control group ,there was an increase in serum level of MDA and a decrease in serum level of SOD in the schizophrenia group ,and had statistically signifi‐cant differences（P〈0 .05） .Moreover ,statistically significant differences were found between subjects in the same age group of the two groups（P〈0 .05） .Meanwhile ,serum levels of MDA and SOD were respectively compared in the two groups between different age groups ,it was shown that in the schizophrenia group and healthy control group there were no statistically significant differences of serum levels of MDA and SOD between subjects 50 years old and over and subjects younger than 50 years old（P〉0 .05） .Conclu‐sion The process of oxidative stress exits in patients with schizophrenia ,and oxidative stress may be involved in the occurrence and progression of schizophrenia .Patients′age may not be significantly correlated with schizophrenia .

关 键 词：精神分裂症 丙二醛 超氧化物歧化酶 年龄 

分 类 号：R749.3[医药卫生—神经病学与精神病学]