端粒酶逆转录酶与转录激活蛋白-1在喉癌组织中的表达及相关性研究  

Expression and Relation of TERT and AP-1 in Laryngeal Carcinoma

作　　者：王亚平[1] 陈晨[2] 肖伯奎[2] 李玲香[1] 

机构地区：[1]内蒙古医科大学附属医院耳鼻咽喉科,呼和浩特010059 [2]武汉大学人民医院耳鼻咽喉头颈外科研究所

出　　处：《听力学及言语疾病杂志》2015年第5期493-496,共4页Journal of Audiology and Speech Pathology

摘　　要：目的分析喉癌肿瘤组织中端粒酶逆转录酶(telomerase reverse transcriptase,TERT)与转录激活蛋白-1(acticator protein 1,AP-1)基因mRNA和蛋白表达水平及两者的相关性。方法利用RT-PCR及量子点标记的免疫荧光染色法,检测24例人喉癌组织中TERT和AP-1的表达。结果在喉癌组织中,TERT与AP-1基因mRNA及蛋白表达水平呈显著正相关,相关系数分别为0.574和0.809,有显著统计学意义(P<0.01)。结论 TERT与AP-1在喉癌组织中的表达具有高度一致性。Objective To investigate telomerase reverse transcriptase （TERT ） and acticator protein 1（AP -1） expression and it＇s corroloation in laryngeal carcinoma tissue .Methods 24 human laryngeal carcinoma tissue were analised by RT -PCR and quantum -dot based immunofluorescence assay for the expression of TERT and AP -1 . Results The expression of TERT mRNA and the expression of c -Fos ,c-Jun in laryngeal carcinoma were postive‐ly related .Correlation coefficient was 0 .574 and 0 .809 ,respectivly（P〈0 .01） .Conclusion TERT and AP -1 were expressed at high levels and positively correlated in human laryngeal carcinoma .

关 键 词：喉癌 端粒酶逆转录酶 转录激活蛋白1 

分 类 号：R739.6[医药卫生—肿瘤]