多系统萎缩患者血脂变化与疾病的关系  

Association between serum lipids changes and multiple system atrophy

作　　者：陈亚楠[1] 张旭[1] 朱飞[1] 于生元[1] 郎森阳[1] 王湘庆[1] 

机构地区：[1]解放军总医院神经内科,北京100853

出　　处：《解放军医学院学报》2015年第9期889-891,895,共4页Academic Journal of Chinese PLA Medical School

基　　金：科技创新苗圃基金项目(11KMM07)

摘　　要：目的探讨血脂与典型的突触蛋白病多系统萎缩(multiple system atrophy,MSA)的关系。方法选取2012年4月-2014年4月就诊于本院的MSA患者113例,选取我院体检的健康人员132例,两组年龄、性别、体质量指数之间差异无统计学意义,观察两组总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白(high-density lipoprotein cholesterol,HDL-C)以及载脂蛋白A1(apolipoprotein A-1,Apo A1)和载脂蛋白B(apolipoproteins B,ApoB)等变化,并采用Logistic回归分析MSA患者的危险因素。结果 MSA组TC(4.31±0.72)mmol/L、TG(1.17±0.47)mmol/L、LDL-C(2.66±0.56)mmol/L、Apo A1(1.17±0.21)g/L、ApoB(0.86±0.16)g/L均低于健康对照组[TC(4.70±0.99)mmol/L、TG(1.42±0.84)mmol/L、LDL-C(2.94±0.85)mmol/L、Apo A1(1.28±0.27)g/L、ApoB(0.92±0.22)g/L,P<0.05];其中MSA-c型患者TG(1.33±0.63)mmol/L、ApoB(0.89±0.15)g/L与健康对照组差异无统计学意义(P>0.05),且MSA-c型和MSA-p型与健康对照组的HDL-C差异均无统计学意义(P>0.05)。多因素分析结果显示,TC、LDL-C、Apo A1、ApoB降低为MSA的危险因素(P<0.05)。结论 MSA患者TC、TG、LDL-C、Apo A1、ApoB均较对照组低,低TC、LDL-C、Apo A1、ApoB为MSA的危险因素。Objective To investigate the association between multiple system atrophy（MSA） and serum lipids. Methods One hundred and thirteen patients with MSA admitted to Chinese PLA General Hospital from April 2012 to April 2014, and another 132 age- and gender-matched healthy subjects were enrolled in this study. Patients’ lipid contents, including total cholesterol（TC）, triglyceride（TG）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, apolipoprotein A-1（Apo A1）, apolipoproteins B（ApoB）, were observed. The risk factors of MSA patients were analyzed using logistic regression analysis. Results Serum lipids like TC, TG, LDL-C and ApoB were significantly lower in MSA patients than in controls（TC： 4.31 mmol/L vs 4.70 mmol/L, P=0.003; TG： 1.17 mmol/L vs 1.42 mmol/L, P=0.006; LDL-C： 2.66 mmol/L vs 2.94 mmol/L, P=0.013; Apo A1： 1.17 mmol/L vs 1.28 mmol/L, P=0.006; ApoB： 0.86 mmol/L vs 0.92 mmol/L, P=0.021）. While, the levels of TG and apo B showed no significant differences between MSA-c patients and controls（P 〉0.05）, and HDL-C level showed no significant differences between MSA-c, MSA-p and controls. The multivariate analysis showed that decreased level of TC, LDL-C, Apo A1 and ApoB were risk factors of MSA. Conclusion The levels of TC, TG, LDL-C, Apo A1 and ApoB is lower in MSA than in controls, and the decreased level of TC, LDL-c, Apo A1 and ApoB are the risk factors of MSA.

关 键 词：总胆固醇 三酰甘油 低密度脂蛋白 多系统萎缩 

分 类 号：R741[医药卫生—神经病学与精神病学]