Autophagy in cerebral ischemia and the effects of traditional Chinese medicine  

作　　者：Xiao-ping Huang Huang Ding Jin-dong Lu Ying-hong Tang Bing-xiang Deng Chang-qing Deng 

机构地区：[1]Molecular Pathology Laboratory, Hunan University of Chinese Medicine [2]Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-cerebral Diseases [3]Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques

出　　处：《Journal of Integrative Medicine》2015年第5期289-296,共8页结合医学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 81102557);the Aid Project for Innovation Platform Open Fund of Hunan Province University (No. 14K068);the Key Project of Administration of Traditional Chinese Medicine of Hunan Province (No. 201301, No. 201508);General Project of Science and Technology Department of Hunan Province (No. 2014SK3001);the Ministry of Education Key Laboratory Open Fund Established by the Province and the Ministry (No. ZYNK201405);the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province;the Hunan Province Natural Science Innovation Group

摘　　要：Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as well as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine （TCM） have been found to modulate the levels of autophagy in tumor cells, nerve cells, myocardial cells and endothelial cells. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can significantly reduce dependence and improve the quality of life of stroke survivors. In healthy cells, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cell death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as well as its roles in cerebral ischemia and the roles of TCM in modulating its activity.Autophagy is a lysosome-mediated degradation process for non-essential or damaged cellular constituents, playing an important homeostatic role in cell survival, differentiation and development to maintain homeostasis. Autophagy is involved in tumors as well as neurodegenerative, cardiovascular and cerebrovascular diseases. Recently, active compounds from traditional Chinese medicine （TCM） have been found to modulate the levels of autophagy in tumor cells, nerve cells, myocardial cells and endothelial cells. Ischemic stroke is a major cause of neurological disability and places a heavy burden on family and society. Regaining function can significantly reduce dependence and improve the quality of life of stroke survivors. In healthy cells, autophagy plays a key role in adapting to nutritional deprivation and eliminating aggregated proteins, however inappropriate activation of autophagy may lead to cell death in cerebral ischemia. This paper reviews the process and the molecular basis of autophagy, as well as its roles in cerebral ischemia and the roles of TCM in modulating its activity.

关 键 词：AUTOPHAGY brain ischemia drugs  Chinese herbal medicine  traditional Chinese review 

分 类 号：R285[医药卫生—中药学]