原发性肝癌射频消融预后的影响因素分析  

Prognostic factors of primary liver RFA analysis

作　　者：李蕊利 万娟[1] 

机构地区：[1]四川大学华西医院肝脏外科,四川成都610041

出　　处：《现代肿瘤医学》2015年第20期2970-2972,共3页Journal of Modern Oncology

基　　金：国家科技重大专项基金资助项目(编号:2008ZX10002-026)

摘　　要：目的:探讨原发性肝癌射频消融预后的影响因素。方法:选取原发性肝癌采取射频消融治疗的患者254例,回顾患者的临床资料,并进行随访,统计患者的生存期。结果:254例患者成功随访218例,随访率85.83%。1年、2年、3年以及5年累积生存率分别为81.19%、67.43%、52.75%和41.28%。不同年龄、术前AFP水平、是否伴有肝硬化和肝炎史、射频次数和引导方式的患者生存期差别不大,无统计学意义(P>0.05)。BCLC分期为A期、肝功能Child分级为A级、肿瘤≤3cm、单发肿瘤、无血管癌栓的患者生存期明显长于其他患者(P<0.05)。经多因素分析,肿瘤BCLC分期、肝功能分级、肿瘤大小、肿瘤数量以及是否有血管癌栓形成是影响肝癌射频消融治疗患者预后的独立因素。结论:射频消融术是治疗肝癌的重要手段,其治疗效果受到多种因素的影响,在对患者进行治疗前通过相关因素评价可以更好的选择治疗的适应证,并对患者的预后进行评价,提高肝癌治疗水平。Objective:To investigate the influential factors of primary liver cancer prognosis treated by radiofre-quency ablation.Methods:To select 245 primary liver cancer patients radiofrequency ablation review clinical data and follow -up.Results:In 254 patients 218 cases were followed up follow -up rate was 85.83%.1 year,2 years,3 years and 5 years cumulative survival rates were 81.19%,67.43%,52.75% and 41.28%.Age,preoperative AFP level, cirrhosis of the liver,hepatitis history,radio frequency were not related with survival (P >0.05).A BCLC staging of liver function Child graded as A grade,tumor ≤3cm,single tumor and no vascular thrombosis of survival was signifi-cantly longer than the other patients (P <0.05).By multivariate analysis,tumor BCLC stage,liver function grade, tumor size,and the number of vascular tumor thrombus were independent prognostic factors of radiofrequency abla-tion.Conclusion:Radiofrequency ablation is an important mean of treatment of liver cancer,its treatment effect is af-fected by many factors,before the patient can be treated by the relevant factor evaluation can better select treatment indications,and evaluate patient outcomes.

关 键 词：原发性肝癌 射频消融 预后 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]