FAP在大肠癌中表达的临床病理意义  

The clinical pathological implication of FAP expression in colorectal carcinoma and their significances

作　　者：王岩[1] 聂明豪[1] 卢艳红[1] 王锐[1] 李晋[1] 杨彬[1] 张海洋[1] 夏明阳[1] 李秀荣[1] 

机构地区：[1]黑龙江省医院病理科,黑龙江哈尔滨150036

出　　处：《现代肿瘤医学》2015年第20期2979-2981,共3页Journal of Modern Oncology

基　　金：黑龙江省卫生厅基金项目(编号:2012-347)

摘　　要：目的:探讨人大肠癌组织中FAP表达与其临床病理特征的关系。方法:采用免疫组化EN法检测1 4 5例大肠癌组织中FAP的表达。结果:FAP半定量计数、表达浓度与肿瘤分期呈正相关(P=0.02,P=0.01),即在临床分期高的肿瘤组织中,FAP表达的量及浓度都显著增高;FAP染色与肿瘤分级之间没有明显的相关性(P>0.05)。结论:FAP高表达可能与大肠癌的浸润生长及转移有密切关系。Objective:To investigate the expression of FAP in human colorectal carcinoma and the relationship be-tween the expression and clinicopathological features.Methods:The expression of FAP was detected by immunohisto-chemical EN technique in 145 cases of colorectal carcinoma.Results:Stromal FAP intensity and semiquantitative a-nalysis were positively correlated to cancer stage(P <0.05).There was no correlation of FAP staining with tumor grade.Conclusion:The expression of FAP in colorectal carcinoma is related with tumor aggressiveness and metasta-sis.Detection of FAP expression might be helpful in the evaluation of the prognostic factors in patients with colorectal carcinoma.

关 键 词：大肠癌 临床病理 

分 类 号：R735.3[医药卫生—肿瘤]