动脉弹性系数对新生儿缺血缺氧性脑病的诊断价值  

The Diagnostic Value of Arterial Elasticity Coefficient for Neonatal Hypoxic-ischemic Encephalopathy

作　　者：郭清皓[1] 陈阵[1] 杨世疆[1] 艾芬[1] 

机构地区：[1]华中科技大学同济医学院附属武汉市中心医院急诊科,武汉430014

出　　处：《临床误诊误治》2015年第9期44-47,共4页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨动脉弹性系数对新生儿缺血缺氧性脑病(hypoxic ischemic encephalopathy,HIE)的诊断价值。方法选择我院2014年7月—2015年7月确诊的HIE足月新生儿作为试验组,另选择同期健康的足月新生儿20例作为对照组。使用Dy SApulse200M动脉弹性功能测定仪测定两组的动脉弹性系数及血流参数,并分析其相关性。结果本研究共纳入26例符合要求的HIE患儿,其中轻度、中度、重度患儿分别为6、13、7例,3组HIE患儿基线资料可比。与对照组比较,试验组大动脉弹性系数(C1)、收缩期峰值流速(PSFV)、舒张末期速度(EDFV)、时间平均流速(TMFV)显著降低(P<0.05),小动脉弹性系数(C2)、阻力指数(RI)、搏动指数(PI)则未见显著差异(P>0.05);随着HIE患儿病情分级的加重,C1、PSFV、EDFV、TMFV的水平均显著降低(P<0.05);相关性分析示:C1、PSFV、EDFV、TMFV的水平与HIE危重度分级均呈显著负相关,差异均有统计学意义(P<0.05)。结论 C1与HIE密切相关,且与PSFV、EDFV、TMFV等经典的评测指标相比展现出良好的相关性,对临床评估新生儿颅脑损伤程度具有重要指导意义。Objective To evaluate the diagnostic value of arterial elasticity coefficient for neonatal hypoxic-ischemic encephalopathy （ HIE） . Methods HIE full-term infants born during July 2014 and July 2015 were selected as experimental group and another 20 full-term newborns in the same period were selected as the healthy control group. DySApulse200M arteri-al elasticity meter measurement of arterial elasticity of two subjects was used to observe the differences. Results 26 HIE chil-dren enrolled met the requirements and the mild, moderate, and severe cases were 6 cases, 13 cases and 7 cases. Baseline data of the 3 groups were compared. Compared with the healthy control group, C1 PSFV, EDFV and TMFV were significantly reduced （P〈0. 05）;C2, RI and PI had no significant difference （P〉0. 05）;with the grading of HIE children aggravated, C1, PSFV, EDFV and TMFV levels were significantly reduced; correlation analysis showed that C1, PSFV, EDFV, TMFV HIE critical levels and grading had significant negative correlation and the differences were statistically significant （ P 〈0. 05 ） . Conclusion C1 is closely associated with HIE, and comparison with PSFV, EDFV, TMFV and other classic evalua-tion indicators show a good correlation and have important guiding significance in assessing the degree of brain injury in new born infants.

关 键 词：缺氧缺血 脑 婴儿 新生 动脉弹性系数 诊断 

分 类 号：R742[医药卫生—神经病学与精神病学]