不同放疗法对脑胶质瘤的疗效比较  

Comparison of Different Methods for The Efficacy of Radiotherapy of Gliomas

作　　者：卢庆刚[1] 牟安娜[1] 朱礼[1] 

机构地区：[1]辽宁省肿瘤医院放疗一科,辽宁沈阳110042

出　　处：《航空航天医学杂志》2015年第9期1067-1069,共3页Journal of Aerospace medicine

摘　　要：目的比较脑胶质瘤术后普通放射治疗与调强放射治疗的疗效。方法选取2002年1月-2011年1月174例颅内占位经术后病理诊断为脑胶质瘤的患者为研究对象，根据不同的放疗方式分为普放组及调强放射治疗组，常规放疗组先给予全脑或次全脑放疗36～40Gy，后针对瘤床野加量至56—60Gy。调强放射治疗采用CT／MRI融合法描画靶区，肿瘤靶体积（GTV）他加权FLAIR序列的MRI图像显示的高信号水肿区，计划靶体积（PTV）为高信号区外放3cm及水肿带。95％的PIV每次计量曲线为2．0Gy，总DT60Gy／30次，共42天。比较不同放疗方式对脑胶质瘤术后的疗效。结果常规放疗组与IMRT组，近期疗效比较无显著性差异，但IMRT组3年总生存率及无进展生存率较常规放疗组好。且放射行损伤较常规放疗组小。结论与常规放疗组比较，IM-RT显著提高脑胶质瘤术后患者的3年总生存率及无进展生存率，并能显著减轻放射性损伤。Objective To compare the efficacy of conventional radiotherapy and intensity - modulated radiation therapy （IMRT） for postoperative gliomas. Methods From January 2002 to January 2011,174 patients of Intracranial lesions through the postoperative pathological diagnosis was gliomaso Patients were classified into conventional radiotherapy and IMRT according to the radiotherapy techniques, conventional radiotherapy group was given the whole brain or subtotal brain irradiation at 36 -40 Gy followed by a boost of 20 Gy to the tumor bed. IMRT using CT/MRI fusion method to target area,GTV was defined as the high signal area on T2 weighted FLAIR MRI image. and PTV was defined as GTV plus a 3 -cm margin and edema zone. Each measurement curves of 95% PTV was 2. 0 Gy, total DT60 Gy/30, total of 42 days. Compared efficacy of different radiotherapy methods on the of gliomas afer operation. Results There was no significant difference in short - term effect comparison at different groups. But IMRT group has good 3 years overall survival and progression free survival compared with conventional radiotherapy group. And the less radiation damage than conventional radiotherapy group. Conclusions Compared conventional radiotherapy, IMRT reduced the radiation damage, Significantly improved the brain glioma patients after 3 year overall survival and progression free survival rate.

关 键 词：放疗 脑胶质瘤 

分 类 号：R739.4[医药卫生—肿瘤]