正交试验法优选复方淫羊藿咀嚼片的提取工艺  

Optimization of the Extraction Technology of Compound Epimedium Chewable Tablets by Orthogonal Test

作　　者：牟婵[1] 周若鹏 赖滢滢 

机构地区：[1]广东药学院中药学院,广州510006 [2]广州奇绩医药科技有限公司,广州510663

出　　处：《中国药房》2015年第28期3986-3988,共3页China Pharmacy

摘　　要：目的:优选复方淫羊藿咀嚼片的提取工艺。方法:以淫羊藿苷提取率、粗多糖含量和浸膏得率为综合指标,采用正交试验法考察加水倍量、提取时间、提取次数对提取效果的影响,优化提取工艺并进行验证试验。结果:最优提取工艺为药材加6倍量水提取3次,每次提取2 h。验证试验显示,淫羊藿苷提取率均值为(83.80±0.02)%,粗多糖含量均值为(29.28±0.55)mg/g,浸膏得率均值为(28.47±0.29)%,RSD均≤0.55%(n=3)。结论:优选的工艺稳定,可用于复方淫羊藿咀嚼片的提取。OBJECTIVE：To optimize the extraction technology of Compound epimedium chewable tablets. METHODS：Using the extraction rate of icariin,the content of crude polysaccharide and yield of extractum as index,the effects of water amount,ex-traction time and extraction times on extraction effect were investigated by orthogonal test. The extraction technology was optimized and validation test was conducted. RESULTS：The optimized extraction technology was as follows as 6-fold water,extracting 3 times,2 h each time. The validation test showed that the average extraction rate of icariin was（83.80±0.02）%,the average con-tent of crude polysaccharide was （29.28 ± 0.55） mg/g,and the average yield of extractum was （28.47 ± 0.29）%（RSD≤0.55%, n=3）. CONCLUSIONS：The optimized extraction technology is stable,and can be used for the extraction of Compound epimedi-um chewable tablets.

关 键 词：复方淫羊藿咀嚼片 淫羊藿苷 粗多糖 正交试验 提取工艺 

分 类 号：R284.2[医药卫生—中药学]