调神针法配合黛力新治疗脑卒中后抑郁疗效观察  

Observation of Therapeutic Effect of Acupuncture Treatment Combined with Fluoxetine hydrochloride Intake for Treating Post-stroke Depression

作　　者：黄捷 李宝栋[2] 张世亮[3] 王宁宁 于文武 孙维明 孙喜凤 王海霞 刘林林 王占强 高青青 时婧 

机构地区：[1]河北省沧州市人民医院神经内科,沧州061000 [2]河北省沧州中西医结合医院神经内科,沧州061001 [3]河北省沧州市中心医院针灸康复科,沧州061001

出　　处：《世界中医药》2015年第8期1238-1241,共4页World Chinese Medicine

基　　金：河北省中医药管理局科技支撑项目(编号:2015300)--课题名称:复荣胶囊对急性脑卒中(气虚血瘀性)神经功能评价及血同型半胱氨酸的影响研究

摘　　要：目的:观察调神针法对脑卒中后抑郁患者疗效的影响。方法:将90例患者按随机数字表法随机分为综合组、调神针法组、黛力新组,每组30例。调神针法组采用调神针法治疗,选用百会、风府、神庭、水沟、大椎、神道等穴,1次/d,每周5次;黛力新组口服盐酸氟西汀(黛力新)治疗,3粒/次,3次/d;综合组采用调神针法治疗加口服黛力新,方法同调神针法组和黛力新组。3组均4周为1个疗程,共治疗6个疗程。比较3组临床疗效、汉密尔顿抑郁量表(HAMD)评分的变化以及不良反应发生情况。结果:综合组总有效率为96.7%(29/30),优于调神针法组的83.3%(25/30)及黛力新组的80.0%(24/30)。3组治疗4周、12周、24周后HAMD评分均较治疗前显著降低(均P<0.05),且综合组在治疗后各时点均低于其他2组(均P<0.05);调神针法组在治疗4周、12周后与黛力新组同期比较差异均无统计学意义(均P>0.05),在治疗24周后HAMD评分低于黛力新组(P<0.05)。综合组出现不良反应者2例,黛力新组6例,调神针法组无不良反应发生。结论:调神针法治疗联合口服黛力新治疗,在临床疗效、抑郁状态改善方面均优于单纯口服黛力新治疗和单纯调神针法治疗。单纯调神针法治疗虽然在临床疗效方面与单纯黛力新治疗没有显著差异,但远期HAMD评分方面及安全性方面优于单纯黛力新治疗。Objective：To observe the effect of acupuncture on patients with post stroke depression.Methods：A total of 90 pa-tients were randomly divided into combined treatment group,acupuncture group,fluoxetine hydrochloride group and there were 30 cases in each group.The acupuncture group received acupuncture treatment on Baihui,Fengfu,Shenting,Shuigou,Dazhui, Shendao and other acupoints,once a day,5 times a week.Fluoxetine hydrochloride group was given fluoxetine hydrochloride,3 tablets each time,3 times daily.Comprehensive group receive treatment combined acupuncture and fluoxetine hydrochloride.All of three groups received treatment for 3 weeks of a course,a total of 6 courses of treatment.The clinical efficacy,Hamilton De-pression Rating Scale（HAMD）score,and the adverse reactions were compared in the three groups.Results：The total efficiency rate of the comprehensive group was 96.7%（29 /30）,better than acupuncture group of 83.3%（25 /30）and fluoxetine hydro-chloride group 80.0%（24 /30）.The HAMD scores in 3 groups was significantly reduced（P 〈0.05）after 4 weeks,1 2 weeks,24 weeks of treatment.The comprehensive group at each time point were lower than the other two groups（P 〈0.05）;after 4 weeks and 1 2 weeks of treatment the acupuncture group and fluoxetine hydrochloride group showed no statistical significance（P 〉0.05） and after treatment of 24 weeks,the acupuncture group’s HAMD score became lower than fluoxetine hydrochloride group（P 〈0.05）.There were 2 cases of adverse reactions in the comprehensive group,6 cases in fluoxetine hydrochloride group,and acu-puncture group had no cases showing adverse reactions.Conclusion：Acupuncture treatment combined with oral Deanxit treatment has better clinical efficacy than only oral fluoxetine hydrochloride treatment or just acupuncture treatment.Acupuncture treatment while had no significant difference comparing to fluoxetine hydrochloride treatment in clinical curative effect,but long-term HAMD score and safety is superior to fluox

关 键 词：脑卒中后抑郁 调神针法 针刺疗法 黛力新 汉密尔顿抑郁量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]