服用胶原蛋白肽Peptan对膝骨关节炎患者的影响:随机双盲、安慰剂对照的临床研究  

Effects of Peptan collagen peptides on patients with knee osteoarthritis: a double-blind, randomized, placebo-controlled clinical study

作　　者：蒋建新[1] 张先龙[1] 金东旭[1] 唐明杰[1] 虞申[1] 樊家珠[2] 黄琪仁[3] 张长青[1] 

机构地区：[1]上海交通大学附属第六人民医院骨科,200233 [2]上海交通大学附属第六人民医院科研科,200233 [3]上海交通大学附属第六人民医院骨质疏松和骨病科,200233

出　　处：《中华临床医师杂志（电子版）》2015年第15期36-39,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的采用随机双盲、安慰剂对照的前瞻性研究,评估服用胶原蛋白肽Peptan对中老年女性膝骨关节炎患者的效果。方法 100例膝骨关节炎患者随机分成两组,试验组服用胶原蛋白肽Peptan 8 g/d,安慰剂组服用麦芽糊精8 g/d,连续服用6个月。应用WOMAC评分和Lysholm评分来评估治疗前后骨关节疼痛和功能改善状况。结果 (1)服用6个月Peptan组WOMAC评分(11.33±4.28)明显低于安慰剂组(15.00±3.45,P<0.001);Peptan组Lysholm评分(85.24±8.88)明显高于安慰剂组(79.73±9.62,P<0.001);(2)两组WOMAC评分和Lysholm评分治疗前后的差值具有明显统计学差异(P<0.001);(3)服用6个月Peptan组的临床效果(关节疼痛好转和功能恢复情况)明显优于安慰剂组(P<0.001)。结论口服胶原蛋白肽Peptan能有效地改善中老年膝骨关节炎女性患者的关节功能,缓解疼痛,改善生活质量。Objective Using a double-blind, randomized, placebo-controled study for evaluating effectivity of oral Peptan colagen peptides treatment in female patients with knee osteoarthritis （OA）.Methods100 patients were randomly assigned to two groups, respectively taking Peptan？ collagen peptides （CP） 8 g （n=50） or placebo （n=50） daily for 6 months. Each subject was evaluated for knee joint pain and function by using the standard tools （WOMAC scores and Lysholm scores）. Results（1）CP groupvs. placebo group, WOMAC scores were lower （11.33±4.28vs. 15.00±3.45）, and Lysholm scores were higher （85.24±8.88vs. 79.73±9.62） for 6 months （P〈0.001）; （2）The difference of WOMAC score and Lysholm score of post- and pre-study between CP group and placebo group was statisticaly significant （P〈0.001）; （3）The proportion of clinical effect was also found significant difference between the placebo group and the CP group for 6 months （P〈0.001）.Conclusion Oral Peptan colagen peptides can effectively improve patients’ knee osteoarthritis function, reduce joint pain and improve the quality of life.

关 键 词：骨关节炎 膝 WOMAC评分 Lysholm评分 胶原蛋白肽 

分 类 号：R684.3[医药卫生—骨科学]