早期肠内营养联合双歧杆菌三联活菌胶囊治疗重症急性胰腺炎的疗效及对炎性因子、肠黏膜屏障功能保护的影响  

Effect of early enteral nutrition with live combined bifidobacterium,lactobacillus and enterococcus capsules on inflammatory factors and intestinal mucosal barrier function in treatment of severe acute pancreatitis

作　　者：蒋欢[1] 蒋丽琳[1] 张凯[2] 肖南平[1] 

机构地区：[1]广元市第一人民医院消化科,四川广元628017 [2]广元市第一人民医院普外科,四川广元628017

出　　处：《海南医学院学报》2015年第11期1496-1498,共3页Journal of Hainan Medical University

基　　金：四川省科技支撑计划项目(2014FZ0278)~~

摘　　要：目的:探索早期肠内营养联合双歧杆菌三联活菌胶囊治疗重症急性胰腺炎(SAP)的疗效及对患者血清炎性因子、肠黏膜屏障功能的影响。方法:选择118例SAP患者,随机分为两组,对照组59例采取早期肠内营养治疗,而观察组59例采取早期肠内营养联合双歧杆菌三联活菌胶囊治疗,比较两组临床疗效及患者炎性因子水平和肠黏膜屏障功能指标变化。结果:观察组腹痛消失时间、腹胀消失时间、排气功能恢复时间均较对照组明显减少,差异具有统计学意义(P<0.05);观察组治疗后白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)均较治疗前明显降低,且明显低于对照组治疗后,差异均具有统计学意义(P<0.05);观察组治疗后D-乳酸、血清二胺氧化酶(DAO)、内毒素、尿乳果糖/甘露醇(L/M)值均较治疗前明显降低,且明显低于对照组治疗后,差异均具有统计学意义(P<0.05)。结论:早期肠内营养联合双歧杆菌三联活菌胶囊治疗SAP效果明显,可迅速改善患者症状,减轻炎症反应,促进肠道黏膜功能恢复,值得临床借鉴和推广应用。Objective： To explore the effect of early enteral nutrition with live combined bifidobacterium, lactobacillus and enterococcus capsules on inflammatory factors and intestinal mucosal barrier function in treatment of severe acute pancrea- titis. Methods： A total of 118 cases of severe acute panereatitis were randomly divided into two groups. The control group （59 cases） patients were treated with early enteral nutrition therapy, while the observation group （59 cases） were treated with early enteral nutrition with live combined bifidobacterium,lactobacillus and enterococcus capsules. The clinical efficacy of the two groups and the changes of the levels of inflammatory factors and the function of intestinal mueosal barrier were compared. Resuits： The time of abdominal pain disappearance, the abdominal distension disappeared, and the recovery time of the exhaust function of the observation group were significantly decreased compared with the control group （P〈0.05）. IL-6, IL-8, TNF - and CRP of observation group were significantly lower compared with those before treatment （P〈0.05） and was significantly lower than that of the control group （P〈0.05）. After treatment, D-lactate, DAO, endotoxin and exami of observation group were decreased significantly compared with those before treatment （P〈0.05） and was significantly lower than that of the control group （P〈0.05）. Conclusions： Eearly enteral nutrition with live combined bifidohacterium,lactobacillus and enterococcus capsules has influence on inflammatory factors and intestinal mucosal barrier function in treatment of severe acute panereatitis. It can rapidly improve the symptoms of patients, reduce inflammation, promote the recovery of intestinal mucosal barrier function, and it is worth clinical application.

关 键 词：早期肠内营养 双歧杆菌三联活菌胶囊 重症胰腺炎 

分 类 号：R576[医药卫生—消化系统]