全程局部同步推量适形放疗联合常规化疗用于进展期中心型非小细胞肺癌中的应用价值  

Effect of SIB-CR combined with conventional chemotherapy on advanced central type of nonsmall cell lung cancer

作　　者：刘尧[1] 王宇[2] 赵东利[3] 闫晓红[1] 杨乔[1] 杨哲[1] 周海平[1] 耿熠[1] 

机构地区：[1]宝鸡市中心医院肿瘤内科,陕西宝鸡721008 [2]第四军医大学西京医院肿瘤中心,陕西西安710032 [3]西安交通大学第一附属医院肿瘤医院肿瘤放射治疗中心,陕西西安710061

出　　处：《海南医学院学报》2015年第11期1574-1577,共4页Journal of Hainan Medical University

摘　　要：目的:研究全程局部同步推量适形放疗联合常规化疗用于进展期中心型非小细胞肺癌中的应用价值。方法:将60例进展期中心型非小细胞肺癌患者随机分为两组,SIB-CR组接受全程局部同步推量适形放疗联合化疗,常规放疗组接受常规放疗联合化疗,检测肺癌组织中细胞凋亡情况、抗凋亡分子和促凋亡分子的蛋白含量以及血清中肺癌活力指标。结果:与常规放疗组比较,SIB-CR组肺癌组织的凋亡指数明显升高,Fas、FasL含量较高,而Bcl-2、Pim-1含量较低,差异均有统计学意义(P<0.05);SIBCR组血清中Cyfra21-1、SCC、TSGF的含量低于常规放疗组,差异有统计学意义(P<0.05)。结论:全程局部同步推量适形放疗联合常规化疗能够诱导肺癌细胞凋亡、调节促凋亡和抗凋亡基因的表达,对肺癌细胞的杀伤效应优于常规放疗。Objective： To study the effect of SIB-CR combined with conventional chemotherapy on advanced central type of non-small cell lung cancer. Methods： A total of 60 patients with advanced central type of non-small cell lung cancer were ran- domly divided into two groups. SIB-CR group received simultaneous integrated boost conformal radiotherapy combined with chemotherapy, and conventional radiotherapy group received conventional radiotherapy combined with chemotherapy. Then cell apoptosis, protein contents of anti-apoptotic molecules and pro-apoptotic molecules in lung cancer tissue as well as lung cancer vitality indicators in serum were detected. Results： Compared with conventional radiotherapy group, apoptotic indexes in lung cancer tissue of SIB-CR group significantly increased; Fas and FasL contents were higher while Bcl-2 and Pim-1 contents were lower; serum Cyfra21-1, SCC and TSGF contents of SIB-CR group were lower than those of conventional radiotherapy group.Conclusion： SIB-CR combined with conventional chemotherapy can induce lung cancer cell apoptosis and regulate the expression of pro-apoptotic and anti-apoptotic genes; its killing ef-ect on lung cancer cells is superior to that of conventional radiotherapy.

关 键 词：非小细胞肺癌 全程局部同步推量适形放疗 凋亡 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]