前房内注入头孢呋辛预防白内障术后眼内炎的Meta分析  

Effects of intracameral cefuroxime injection on the prophylaxis of endophthalmitis after cataract surgeries:a Meta-analysis

作　　者：吴晓玉[1] 蒋林志[2] 

机构地区：[1]中国人民解放军第180医院眼科,中国福建省泉州市362000 [2]广西医科大学第一附属医院眼科,中国广西壮族自治区南宁市530021

出　　处：《国际眼科杂志》2015年第10期1753-1756,共4页International Eye Science

摘　　要：目的：通过检索收集国内外文献,运用Meta分析方法,比较前房内注入头孢呋辛与对照组无干预措施后白内障术后眼内炎的发病情况,评价前房内注入头孢呋辛对白内障术后眼内炎的预防作用。 方法：检索国内外数据库如 Pubmed、The Cochrane Library、EMBASE、维普中文科技期刊数据库、中国知网、万方数据库经审稿人审核发表选取2006-01-01/2015-01-31的关于前房内注入头孢呋辛与对照组无干预措施对白内障术后眼内炎预防作用的文章,共纳入5篇文献,通过提取数据,观察采取与未采取该预防措施后白内障术后眼内炎的发病率,应用Review Manager 5.2软件,采用固定效应模型,统计比较OR值和95%CI,进行敏感性分析,排除异质性,得出结果。 结果：Meta分析比较前房内注入头孢呋辛与对照组,以白内障术后眼内炎的发病率作为指标,统计结果差异有明显的统计学意义（ OR=0.11,95%CI=0.07~0.18,P〈0.01）,提示前房内注入头孢呋辛组与未注入头孢呋辛对照组的差异有统计学意义。 结论：前房内注入头孢呋辛可有效地降低白内障术后眼内炎的发生。AIM： To evaluate the effects of intracameral cefuroxime injection on the prophylaxis of postoperative endophthalmitis after cataract surgeries, and compare endophthalmitis conditions between intracameral cefuroxime injection group and no intervention control group, using Meta analysis to search literatures at home and abroad. METHODS： By searching through Pubmed, the Cochrane Library, EMBASE, QVIP, CNKI, Wanfang, the literatures published from January 1 st 2006 to January 31 rd 2015 were collected. The data in five literatures about the effects of intracameral cefuroxime injection on the prophylaxis of endophthalmitis after cataract surgeries were analyzed. By extracting data, incidence of endophthalmitis after cataract surgeries with taking the preventive measures or not taking was compared by Review Manager 5. 2. Adopting fixed effect model, values of odds ratio （ OR） and 95% Confidence Interval （ 95% CI ） were recorded and compared, analyzed sensitivity analysis, excluded heterogeneity and calculated outcomes. RESULTS： After comparing the incidence ofendophthalmitis from intracameral cefuroxime injection group and control group, the result was statistically significant [OR=0. 11 （P〈0. 01）;95% CI：0. 07~0. 18].CONCLUSION：Intracameral cefuroxime injection can effectively decrease the occurrence of endophthalmitis after cataract surgeries.

关 键 词：眼内炎 白内障 头孢呋辛 

分 类 号：R779.66[医药卫生—眼科]