老年胆道感染患者血清降钙素原及白介素-6水平测定的临床意义  

Clinical significance of serum procalcitonin and interleukin-6 in diagnosis of biliary infection in the elderly patients

作　　者：曹鸿霞[1] 章礼久[1] 

机构地区：[1]安徽医科大学第二附属医院消化内科,安徽省合肥市230601

出　　处：《实用老年医学》2015年第7期566-567,570,共3页Practical Geriatrics

摘　　要：目的评价血清降钙素原(PCT)、白介素-6(IL-6)和白细胞(WBC)水平在老年胆道感染患者中的诊断价值。方法收集100例年龄≥60岁胆道感染患者(感染组),以及20例非胆道感染老年人(对照组)。入院后24 h内对PCT、IL-6采用免疫荧光法进行检测,同时记录各组患者外周血常规及细菌培养结果。结果胆道感染组PCT、IL-6水平显著高于对照组(P<0.05),ROC曲线下面积(AUC)均>0.5。诊断老年胆道感染PCT的灵敏度为91%,特异度为50%,截断值为0.0365 ng/ml;IL-6的灵敏度为94%,特异度为50%。结论 PCT和IL-6在诊断胆道感染中具有重要临床意义。Objective To evaluate the clinical value of serum procalcitonin （PCT） and interleukin-6 （IL-6） in the diagnosis of biliary infection in the elderly patients. Methods 100 patients （aged ≥ 60 years） with biliary infection in our hospital from January 2013 to October 2014 were collected in the study, and 20 aged people without biliary infection were selected as control group. The levels of serum PCT, IL-6 and WBC were detected in 24 hours by using immunofluores- cence assay. Results The levels of PCT and IL-6 in the patients with biliary infection were significantly higher than those in control group （P〈0. 05）. Depending on receiver operator characteristic （ROC） curves, the best cutoff point of PCT for diagnosis for biliary infection was 0. 0365 ng/ml, （sensitivity 91%, specificity 50%）, and the cutoff point of IL-6 for diag- nosis for biliary infection was 7.5 pg/ml （ sensitivity 94%, specificity 50%）. Conclusions PCT and IL-6 have higher sensitivity for biliary infection in the elderly patients, which shows important value in the diagnosis for biiiary infection.

关 键 词：胆道感染 降钙素原 白介素-6 

分 类 号：R575.7[医药卫生—消化系统]