5种药用植物对小鼠的降血糖作用  被引量：8

Effect of five Chinese traditional medicinal plants on lowering blood glucose level to mice</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=6661304' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('8bR39+4uWs/1JVXrQV03hvbUO/KHyLID8V0cNlb5E5s=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="8bR39+4uWs/1JVXrQV03hvbUO/KHyLID8V0cNlb5E5s="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p 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href='/writer/article.aspx?id=100000007908995' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%83%ad%e8%8d%a3%e9%ba%9f%5d' title='郭荣麟[1]'>郭荣麟[1]</a> <a href='/writer/article.aspx?id=100000010882486' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%91%a8%e7%88%b1%e7%8e%b2%5d' title='周爱玲[1]'>周爱玲[1]</a> <a href='/writer/article.aspx?id=100000006092002' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%83%91%e6%b1%89%e8%87%a3%5d' title='郑汉臣[2]'>郑汉臣[2]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=525549&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b1%9f%e8%8b%8f%e7%9c%81%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e6%a4%8d%e7%89%a9%e7%a0%94%e7%a9%b6%e6%89%80%e6%b1%9f%e8%8b%8f%e7%9c%81%e6%a4%8d%e7%89%a9%e8%bf%81%e5%9c%b0%e4%bf%9d%e6%8a%a4%e9%87%8d%e7%82%b9%e5%ae%9e%e9%aa%8c%e5%ae%a4' title='[1]江苏省中国科学院植物研究所江苏省植物迁地保护重点实验室,江苏南京210014'>[1]江苏省中国科学院植物研究所江苏省植物迁地保护重点实验室,江苏南京210014</a> <a href='/organ/article.aspx?id=51973&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e7%ac%ac%e4%ba%8c%e5%86%9b%e5%8c%bb%e5%a4%a7%e5%ad%a6%e8%8d%af%e5%ad%a6%e9%99%a2' title='[2]第二军医大学药学院,上海200433'>[2]第二军医大学药学院,上海200433</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=97383A' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e6%a4%8d%e7%89%a9%e8%b5%84%e6%ba%90%e4%b8%8e%e7%8e%af%e5%a2%83%e5%ad%a6%e6%8a%a5%5d' title='植物资源与环境学报'>《植物资源与环境学报》</a>2002年第2期29-32,共4页<em>Journal of Plant Resources and Environment</em></p><p class='abstrack'><strong>摘　　要：</strong>对菊叶三七(GnuradivaricatiumO.Hoffm.)、仙鹤草(AgrimoniapilosaLedeb.)、夏枯草(PrunellavulgarisL.)、女贞子(LigustrumlucidumAit.)和枸骨(IlexcornutaLindl.etPaxt.)的降糖作用进行了初步的研究。菊叶三七鲜样的水提物(0.2和0.4g kg)及95%乙醇提取物(0.2和0.4g kg)对正常小鼠的血糖有显著的降低作用,干样95%乙醇提取物(0.5、1.0和2.0g kg)对四氧嘧啶糖尿病小鼠的血糖有显著的降低作用,其中鲜样95%乙醇提取物(0 4g kg)的降糖作用优于优降糖,干样95%乙醇提取物(2.0g kg)的降糖作用与降糖灵(0.1g kg)相当。仙鹤草的水煎液(30和60g kg)对正常小鼠的血糖有显著的降低作用,95%乙醇提取物(30、60和120g kg)对四氧嘧啶糖尿病小鼠的血糖均有一定的降低作用。夏枯草的95%乙醇提取物(30、60和120g kg)和女贞子的95%乙醇提取物(11.25和22.50g kg)对四氧嘧啶糖尿病小鼠的血糖均有一定的降低作用。枸骨的正丁醇提取物(30和60g kg)对四氧嘧啶糖尿病小鼠和正常小鼠的血糖均没有影响。实验结果表明,菊叶三七是一种值得开发的降糖植物资源。<em><Abstrcat> Pharmacological experiments of \%Gnura divaricatium \%O. Hoffm., \%Agrimonia pilosa \%Ledeb., \%Prunella vulgaris \%L., \%Ligustrum lucidum \%Ait. and \%Ilex cornuta \%Lindl. et Paxt. on lowering blood glucose were carried out. The water and 95% ethanol extracts (0.2 and 0.4 g/kg) from fresh herbs of \%G. divaricatium \%showed remarkable effects on lowering blood glucose level to normal mice, in which the dose 0.4 g/kg of the 95% ethanol extracts showed more efficiency than glyburide. The 95% ethanol extracts (0.5, 1.0 and 2.0 g/kg) from dried herbs of \%G. divaricatium \%could obviously decrease blood glucose to alloxan diabetic mice, in which the dose 2.0 g/kg of it showed equivalent effect as same as 0.1 g/kg phenformin. The doses 30 and 60 g/kg of the boiled water extracts from \%A. pilosa \%possessed a remarkable effect on lowering blood glucose level to normal mice, while its 95% ethanol extracts (30, 60 and 120 g/kg) played certain role in lowering blood glucose level to alloxan diabetic mice. The 95% ethanol extracts from \%P. vulgaris \%(30, 60 and 120 g/kg) and \%L. lucidum \%(11.25 and 22.50 g/kg) all exerted some effects on lowering blood glucose level to alloxan diabetic mice. However, the \%n\%\|butanol extracts from \%I. cornuta \%(30 and 60 g/kg) had no effect on decreasing blood glucose level to both alloxan diabetic mice and normal mice. The results showed \%G. divaricatium \%was an outstanding plant worthy to be utilized to develop medicines for diabetes mellitus.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=4250568' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%b0%8f%e9%bc%a0%5d' title='小鼠'>小鼠</a> <a href='/subject/article.aspx?id=5914309' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e9%99%8d%e8%a1%80%e7%b3%96%e4%bd%9c%e7%94%a8%5d' title='降血糖作用'>降血糖作用</a> <a href='/subject/article.aspx?id=2527693' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%b3%96%e5%b0%bf%e7%97%85%5d' title='糖尿病'>糖尿病</a> <a href='/subject/article.aspx?id=5086711' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%8f%8a%e5%8f%b6%e4%b8%89%e4%b8%83%5d' title='菊叶三七'>菊叶三七</a> <a href='/subject/article.aspx?id=876019' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%8d%af%e7%94%a8%e6%a4%8d%e7%89%a9%5d' title='药用植物'>药用植物</a> <a href='/subject/article.aspx?id=64191' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%8d%95%e9%aa%8c%e6%96%b9%5d' title='单验方'>单验方</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR282.71' title='R282.71'>R282.71</a>[<a href = '/domain/article.aspx?id=464' >医药卫生—中药学</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=6661304" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" 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