胆汁酸代谢与胆固醇结石病  

Metabolism of bile acid and cholesterol gallstone disease

作　　者：蔡强[1] 韩天权[1] 蒋兆彦[1] 

机构地区：[1]上海交通大学附属瑞金医院外科上海消化外科研究所,上海200025

出　　处：《上海医药》2015年第18期3-6,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金(81070367;81270537)

摘　　要：胆汁酸是胆汁的主要成分,由胆固醇在肝脏内转化合成。胆汁酸具有调节胆固醇饱和度和排除机体过多胆固醇的作用。胆固醇过饱和是胆固醇结石病发病机制中的重要因素。本文综述胆汁酸代谢与胆固醇结石病发病关系的研究进展。Bile acid, a major component of bile, is converted from cholesterol in the liver. It regulates the cholesterol saturation and eliminates excessive cholesterol in the body. Cholesterol supersaturation is regarded as an essential factor for pathogenesis of cholesterol gallstone disease. This paper reviewes the progress in metabolism of bile acid and its relation to cholesterol gallstone disease.

关 键 词：胆汁酸 胆固醇结石病 肝脏 

分 类 号：R575.62[医药卫生—消化系统]