血小板活化在溃疡性结肠炎发病中的作用  

Roles of platelet activation in ulcerative colitis

作　　者：董肖肖[1] 张鸣鸣[1] 姜大磊[1] 钮自宇[1] 李文利[1] 解祥军[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院消化内一科,山东青岛266011

出　　处：《胃肠病学和肝病学杂志》2015年第9期1088-1090,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨血小板活化在溃疡性结肠炎(ulcerative colitis,UC)发生、发展中的作用。方法对80例活动期UC患者(UC组)、20例健康对照者(健康对照组)采用ELISA法检测血浆中血小板活化指标D-二聚体、P-选择素、6-酮-前列腺素F1α(6-ketoprostaglandin,6-K-PGF1α)、血栓素B2(thromboxane B2,TXB2)的水平,比较两组、UC不同严重程度和不同分型间的差异。结果与健康对照组相比,UC组血浆中血小板活化指标D-二聚体、P-选择素、6-K-PGF1α、TXB2均明显升高(P<0.01);随着UC严重化程度的增加,血小板活化指标升高,且轻度组、中度组与重度组比较,差异有统计学意义(P<0.01);慢性复发型及慢性持续型较初发型UC患者各血小板活化指标均明显升高,差异具有统计学意义(P<0.01)。结论 UC患者血小板处于活化状态。血小板活化通过释放多种炎性介质维持结肠黏膜炎症,促进UC的发生、发展,这可能为血小板活化拮抗剂治疗UC提供一定的理论基础。Objective To investigate the role of platelet activation in the development of ulcerative colitis（UC）. Methods D-direct, P-selectin, F1α（6-ketoprostaglandin,6-K-PGF1α）、 , thromboxane B2 （TXB2） in plasma of pa- tients with UC（UC group） and healthy eontrols （healthy control group） were detected by ELISA. The differences be- tween two groups, subgroups of the severity and clinical types were compared. Results Compared with healthy control group, the markers of platelet activation in plasma D-dimer, P-seleetin, （6-K-PGF1α） , TXB2 of UC group were signif- icantly increased （P 〈 0.01 ） ; their expressions were associated with severity and clinical types of UC （P 〈 0. 01 ）. Conclusion Platelet activation involved in the development process of inflammation plays an important role in the path- ogenesis of ulcerative colitis through releasing kinds of inflammatory mediators. This maybe provide a theoretical basis for platelet aetivation antagonists treating UC.

关 键 词：溃疡性结肠炎 血小板活化 P-选择素 6-酮-前列腺素F1Α 血栓素B2 

分 类 号：R574.62[医药卫生—消化系统]