颈动脉粥样硬化与老年血管性痴呆的关系研究  

Correlation of carotid atherosclerosis and senile vascular dementia

作　　者：徐国卫[1] 刘欣[1] 王新成[1] 杨帆[1] 郭达云[1] 

机构地区：[1]郑州大学附属郑州中心医院神经内科,河南郑州450007

出　　处：《河南医学研究》2015年第8期22-24,共3页Henan Medical Research

摘　　要：目的探讨颈动脉粥样硬化与老年血管性痴呆的相关性,为老年血管性痴呆的防治提供临床依据。方法收集68例老年血管性痴呆患者,纳入血管性痴呆组,同时选择同期健康体检者70例作为对照组。比较两组颈总动脉、颈内动脉内径、颈动脉内膜中层厚度(IMT)、颈动脉粥样斑块发生及血脂水平情况。结果血管性痴呆组颈总动脉、颈内动脉内径明显小于对照组,IMT明显高于对照组(P<0.05)。血管性痴呆组粥样硬化斑块发生率明显高于对照组(P<0.05)。血管性痴呆组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)明显高于对照组,高密度脂蛋白胆固醇(HDL-C)明显低于对照组(P<0.05)。结论颈动脉粥样硬化与血管性痴呆存在一定的相关性,采取积极措施预防和抗动脉硬化治疗有利于降低血管性痴呆的发生率。Objective To investigate the correlation of carotid atherosclerosis and senile vascular dementia for providing clini-cal basis for the prevention of senile vascular dementia. Methods 68 patients with senile vascular dementia（the senile vascular dementia group）and 70 health examiners（the control group）were selected. Carotid artery and internal carotid artery diameter, intima - media thickness（IMT）,carotid atheromatous plaque and blood lipid level were compared between the two groups. Re-sults Carotid artery and internal carotid artery diameter of vascular dementia group was obviously less than control group,IMT was significantly higher than the control group（P〈 0. 05）. Atherosclerotic plaques incidence of vascular dementia group was ob-viously higher than that of control group（P〈 0. 05）. The levels of TG,TC,LDL - C vascular dementia group were obviously higher than that of control group,and the levels of HDL - C were significantly lower than the control group（P〈 0. 05）. Conclu-sion Carotid artery atherosclerosis and vascular dementia has a certain relevance. Taking positive measures to prevent and treat atherosclerosis is helpful to reduce the incidence of vascular dementia.

关 键 词：颈动脉粥样硬化 老年血管性痴呆 颈动脉内膜中层厚度 

分 类 号：R749[医药卫生—神经病学与精神病学]